Chlorambucil

Chlorambucil [4- bis(2-chIoroethyl)amino benzene)butyric acid] [305-03-3] M 304.2, m... 

Acetanilide and maleic acid are condensed to give /3-(p-acetaminoben2oyl)acrvlic acid which is hydrogenated to give methyl- y-(p-aminophenyl)butyrate. That is reacted with ethylene oxide and then with phosphorus oxychloride to give the methyl ester which is finally hy-droly2ed to give chlorambucil. 

Chemical Name Prednisolone 21 -[4 -[p-bis(2-chloroethyl)amino] phenyl] butyrate Common Name Prednisolone chlorambucil ester... 

Triethylenemelamine Ethylene oxide Chlorambucil Choline dihydrogen citrate Etofibrate Melphalan Nimorazole Nonoxynol Tyloxapol Uracil mustard... 

Linfolysin - Chlorambucil Linosal - Betamethasone Linostil -Dimetacrine tartrate Linton Haloperidol Linyl - Phentermine HCI Lioresal Baclofen Lipanor - Ciprofibrate Lipenthyl - Fenofibrate Lipentyl - Fenofibrate Lipavil - Clofibrate Lipavlon - Clofibrate Lipenan - Clofibride Lipidax - Fenofibrate Lipidicon - Clofibrate Lipidil - Fenofibrate Lipo - Folic acid Lipo-BC - Inositol... 

According to a hypothesis launched by Larionov et al in the 1960s, some new nitrogen mustard derivatives were developed. They contain metabolites and heterocyclic structures as carriers of the cytotoxic chloroethylamine groups. By this way the synthesis of aliylating metabolites started melphalan (sarcolysine) as L- or DL-phenylalanine derivative prospidine with a tricyclic piperazine moiety and chlorambucil as butyric acid derivative. It was proven that each alkylating metabolite has its own spectrum of selective antitumor activity. 

The malignant cells appear to be more susceptible to the effects of the alkylating drugp. Examples of alkylating drag include busulfan (Myleran, Busulfex) and chlorambucil (Leukeran). 

Dennis, age 10 years, has leukemia and is to begin chemotherapy with chlorambucil (Leukeran). Discuss what information would be important to discuss with Dennis and Ms parents before beginning the treatment regimen. 

Chlorambucil - there is no problem with the quantitation ion (at m/z 254), although the second ion proves to be a little difficult. While the ion at m/z 303 is the obvious choice, this is not very intense and therefore for samples containing small amounts of analyte the precision of measurement of this ion will be reduced and it may not be detectable at all levels at which the quantitation ion is observed. We could possibly consider the (M- -2) ion, as the combination o/m/z 254 (high mass, and therefore reasonable specificity), the presence of one chlorine, and the chromatographic retention time could be considered sufficient for definitive identification in those cases in which the intensity o/m/z 303 is insufficient. 

Fig. 3.11 Alkylating polyamide binding site model and structures of polyamide-alkylator conjugates. The dotted triangle represents the alkylating agent. All other symbols are defined in Fig. 3.4. The CBI and chlorambucil alkylator domains are boxed...

Beryllium and certain compounds Cadmium and certain compounds Carbon tetrachloride Chlorambucil Cyclophosphamide Dimethylcarbamoyl chloride Dimethyl sulphate Ethylene oxide Iron dextran... 

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