Antitumor action

Newer bleomycins such as peplomycin and especially liblomycin, are more resistant to bleomycin hydrolase. This results in less lung toxicity but more bone marrow toxicity, and allows for a different spectmm of antitumor action. Bleomycin is inactive orally it is given intravenously, intramuscularly, subcutaneously, or directiy into a cavity such as the pleural cavity. The majority of dmg is excreted unchanged in the urine. 

The adventitious discovery of the antitumor action of the nitrogen mustard poison war gases led to intensive investigation of the mode of action of these compounds. In brief, it has been fairly well established that these agents owe their effect to the presence of the highly reactive bis(2-chloroethyl)amine group. The cytotoxic activity of... 

The iron(III) complexes of 21 and 22 were shown to be 3 to 6 times more active as inhibitors of partially purified ribonucleotide reductase than un-complexed thiosemicarbazones [128]. The mechanism of antitumor action by these complexes still remains largely speculative, although some excellent preliminary studies have appeared. It has been postulated [148] that tridentate... 

Preliminary observation on 16 cancer patients who have been treated with the above-mentioned total alkaloid preparation indicates that symptoms are improved. Thus hepatic cancer patients have claimed disappearance of pain, improvement of appetite, and reduction of ascites patients suffering esophageal cancer claimed to have the self-feeling of relaxation of pain and disappearance of vomiting and upset stomach as well as the improvement of appetite. These preliminary results are quite encouraging, but certainly more extensive investigations are needed before the antitumor action of the Gelsemium alkaloids can be established. 

Mori K, Toyomasu T, Nanba H and Kuroda H. 1987. Antitumor action and fruit bodies of edible mushrooms orally administered to mice. Mush J Tropics 7 121—126. 

Interferon alfa-2b (Intron A) is a recombinant DNA product derived from the interferon alfa-2b gene of human white blood cells. Its mechanism of antitumor action involves binding to a plasma membrane receptor but is otherwise poorly understood. Its serum half-life is 2 to 3 hours after parenteral administration. 

Aldesleukin (IL-2, Pwleukin) is a human recombinant interleukin-2 protein. Its antitumor action is thought to include multiple effects on the immune system, such as... 

The mode of antitumor action of 60 is activated in vivo by bioreduction of the hydroxylamine moiety (Scheme 9) leading to the ring-expanded product, azocinone 61, which upon cyclization furnishes the mitosene-like 62 <1997T10229>. 

Divya CS, Pillai MR. 2006. Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Mol Carcinog 45 320-332. 

Trimethylgermyl derivatives of 2,-deoxyuridine131 exhibit antimetabolic properties the ft-anomer possesses weak biological action, the a-anomers inhibits the replication of herpes simplex virus HSV-1131 132, reveal cytotoxic properties in vitro experiments on cell culture of human ovary carcinoma CaOv and fail to display antitumor action in vivo to leukemia P388 in mice. The a-anomer of 5-trimethylgermyl-2,-deoxyuridine suppresses the incorporation of 2,-deoxyuridine and thymidine into the DNA of hepatoma 22A cells in vitro more effectively (by 88 and 27%) than the ft-anomer (50 and 0%, respectively). 

Polymeric N-oxides, like 2, show no activity in this test. An activation of the RHS-system has also been supposed to be die reason for the antitumor action of divinyl ether/maleic anhydride copolymers [5] which have been described for the first time by Regelson (32) as interferon inductors. 

Strikingly, tamoxifen, an anticancer agent in chnical use, significantly inhibited K+ currents and proliferation of mouse neuroblastoma cells NG108-15. The effect of tamoxifen on the cell prohferation was well correlated with the effect of tamoxifen on the resting K+ flux, indicating that the antitumor action of tamoxifen could be due to its interaction with K+ channels (Rouzaire-Dubois and Dubois 1990). 

More studies on antitumor action of qinghaosu analogs were reported. °... 

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