Lethal dose in mice

Death. Information regarding death in humans following exposure to 1,2-diphenylhydrazine by any route was not found. Some information is available on lethality of orally-administered 1,2-diphenylhydrazine in animals. This information, consisting of a gavage LDso value in fats (Marhold et al. 1968) and an unreliable 3-day dietary lethal dose in mice (Schafer and Bowles 1985), indicates that single or several oral doses of about 1000 mg/kg/day may be lethal for rodents. Based on these data, 1,2-diphenylhydrazine does not appear to be highly acutely toxic to humans he oral route. 

The minimal lethal dose in mice by subcutaneous injection was 180mg/kg animals developed progressive cyanosis and dyspnea before death at autopsy there were degenerative lesions in the liver, kidneys, and other organs, with evidence of vascular damage. ... 

Acute Toxicities The estimated lethal doses in mice of various PS ODNs with and without 2 -MOE modifications are all approaching 1 g/kg, indicating a low level of acute toxicity in mice (Table 24.2). In monkeys, a high-dose administration of PS ODNs results in the inhibition of factor H of the alternative complement cascade. Factor H is a endogenous inhibitor of the... 

The minimum lethal dose to mice by oral administration that has been reported is 0.25 mg/kg however, lethality fluctuates depending on individuals and age (Ito et al. 2002). Interestingly, the intraperi-toneal and oral lethal doses in mice are fairly close for azaspiracid-1, which is not the case for other groups of marine toxins (Ito et al. 2002 Ito et al. 2000). The relative toxic potency for different analogues is only known for azaspirazids-1 to -5, and the comparison is based in monse lethal doses by intraperitoneal injection. Azaspiracids-1, -2, and -3 are the more toxic forms, with monse lethal doses of 0.2 mg/kg, 0.11 mg/kg, and 0.14 mg/kg, respectively (Ofuji et al. 1999a Satake et al. 1998a), followed by azaspiracid-4 (0.47 mg/kg) and the less toxic azaspiracid-5 (approximately 1.0 mg/kg) (Ofuji etal. 2001). 

For ethical reasons, the first administered dose in humans must not induce any serious toxicity in any patients. The starting dose level is most often one-tenth the lethal dose in mice if it is nontoxic in dog otherwise one-third of the toxic low dose in dog is selected. This is not expected to cause any significant toxicity. 

The puffer fish toxin. Captain Cook severely affected in 1774. The fish is prepared by trained cooks and eaten as fugu in Japan. Also found in ovaries and liver of related fish species and some cephalopods. Non-protein MW 319. Effects numbness and tingling of lips, vomiting, fall in BP, weakness, paralysis, respiratory failure, death. Lethal dose in mice 5 pg/kg among the most potent of toxins. Blocks sodium channels and prevents depolarization. Believed to be produced by bacteria in the fish. Looked at by Japan in WWII as a potential CW agent. 

As a result of improved selectivity, ABT-594 is safer than epibatidine in in vivo testing. The separation between antinociceptive doses and lethal doses in mice is fivefold greater for ABT-594 than it is for epibatidine.37 Similarly, ABT-594 has less seizure liability than epibatidine in mice and displays less cardiovascular toxicity in dogs.37,38... 

Quinidine is more potent than quinine in its action on the cardiovascular system. Overdoses may cause loweriug of blood pressure. Gastric effects are lower thau quiuiue. Toxicity is lower relative to quiuiue subcutaueous lethal dose in mice is 400 mg/kg against 200 mg/kg for quinine. 

The vapors of ethylene bromohydrin are an irritant to the eyes and mucous membranes. It is corrosive to the skin. Ingestion of this compound can produce moderate to severe toxic effects. The target organs are the CNS, gastrointestinal tract, and liver. The lethal dose in mice by the intraperitoneal route was 80 mg/kg. 

There is no report on its oral toxicity. However, it may be highly toxic by intravenous administration. A lethal dose in mice is reported as 10 mg/kg. Its carcinogenic actions in animals is well established. Subcutaneous administration of this compound in mice resulted in tumors at the sites of application. 

The toxic effects are similar to those associated with mustard gas. It is a dangerous vesicant and a highly toxic substance, exhibiting delayed symptoms. Although sesquimustard is less volatile than O-Mustard(T), its toxicity in humans via inhalation route is somewhat greater than that of the latter. The subcutaneous lethal dose in mice is in the range 10 mg/kg. 

A derivative of DDT toxic properties similar to DDT systemic effects from ingestion include headache, anesthesia, cardiac arrhythmias, nausea, vomiting, sweating, and convulsions oral lethal dose in mice 600 mg/kg also moderately toxic by skin absorption susceptible to accumulation in fat sufficient evidence of carcinogenicity in experimental animals. 

Skin absorption and administration by intraperitoneal and intravenous routes exhibited high acute toxicity lethal dose in mice intraperitoneally was 4 mg/kg... 

Dehydrobufotenin a Toad poison (see) found in Bufo marinus M, 202. Minimal lethal dose in mice 6mg/kg. 

The hydrochloride of 3-benzoyloxy-l-azabicyclo(3,2,2)-nonane (LXVII) has a weak hypotensive activity (5-10 mg/kg in anaesthetized cats) a very weak cholinergic activity and no sedative activity. This compound is much more toxic than oxylidine (LXIa), the lethal dose in mice being 50 mg/kg (injected s.c.) and 5 mg/kg (injected i.v.). 

Of the ten presumably new but unclassified alkaloids, isolated by Chou from Corydalis ambigua (Item 8 list, p. 170), four have been examined pharmacologically by Chen, Anderson and Chou, who find that alkaloids B and L, given intravenously in sub-lethal doses, produce catalepsy in mice and monkeys and a similar action is shown by L in cats. (Wang and Lu had already found that B and K resembled bulbocapnine in action.) Alkaloids J and M induce convulsions in lethal, or near lethal, doses in mice. All four have a similar depressant action on the heart in frogs, and in etherised cats they eause a fall in arterial blood pressure. In dilute solution they stimulate isolated rabbit intestine but relax it at higher concentrations. All induce contraction of isolated guinea-pig uterus. The M.L.D. (mgm./kilo.) by intravenous injection in mice are as follows B, 108 J, 42 L, 150 M, 41. 

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