Leishmania mexicana

TKase is a homodimeric protein with a subunit of about 70kDa. The X-ray structures of TKase of E. colif S. cerevisiaeX Leishmania mexicana and mize have been solved. In addition, the crystal structures of a number of site-directed mutants have been determined. Schneider and co-workers have reported a series of studies in which they have mutated important residues of active site of TKase to elucidate the reaction mechanism and explain the origin of the stereospecificity of the C—C bond-forming process (Table The conserved... [Pg.329]

Nugent, P.C., Karsani, S.A., Wait, R., Tempero, J. and Smith, D.F. (2004) Proteomic analysis of Leishmania mexicana differentiation. Molecular and Biochemical Parasitology 1 36, 51-62. [Pg.346]

The pentavalent antimony compound, sodium stibogluconate, is used as an anti-parasitic drug. Treatment of Leishmania braziliensis has been reported to be successful with sodium stibogluconate whereas in Leishmania mexicana, the response was lower and the preferred drug for this disease was ketoconazole . [Pg.720]

Podocalyx loranthoides Klotzseh (leaves and stems) Podoearpusflavone A (6) putraflavone (10). Antiprotozoal activity against Leishmania mexicana promastigotes. Suarez et al., 2003[69] Diaz et al.,2007[318]. [Pg.134]

Talamas-Rohana P, Wright SD, Lennartz MR, Russell DG (1990) Lipophosphoglycan from Leishmania mexicana promastigotes binds to members of the CR3, p 150,95 and LFA-1 family of leukocyte integrals. J Immunol 144 4817—4824... [Pg.15]

Cutaneous leishmaniasis is characterized by one or more slowly healing superficial ulcers that may be painful. These lesions are liable to further infection and may remain as open sores or become hard, wartlike nodules. The form of cutaneous leishmaniasis referred to as New Wodd disease is caused by species of the Leishmania (Viannia) bra iliensis complex (L bra liensis, L gujanensis, L panamanesis, and L peruviana) and species of the Leishmania (Leishmania) mexicana complex (L mexicana, L ama onensis, and L vene uelensis) in the western hemisphere. Old World disease (oriental sore, Delhi or Baghdad boil) is caused by Leishmania tropica and Leishmania major m. Asia, Africa, and southern Europe, and Leishmania aethiopica, restricted to eastern Africa. The incubation period for cutaneous leishmaniasis ranges from a few weeks to several months. Spontaneous cures can take place in a period ranging from one month to several years. [Pg.269]

Leishmaniasis Leishmania brasiliensis Leishmania donovani Leishmania tropica Leishmania mexicana South and Central America S. America and S. Russia Asia, N. Africa, and S. Europe Mexico, Central America, and Amazon basin ... [Pg.276]

Hannaert, V., Blaauw, M., Kohl, L., Allert, S., Opperdoes, F. R. and Michels, P. A. M. (1992) Molecular analysis of the cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana. Mol. Biochem. Parasitol. 55 115 126. [Pg.31]

Mottram, J. C. and Coombs G. H. (1985) Leishmania mexicana enzyme activities of amastigotes and promastigotes and their inhibition by antimonials and arsenicals. Exp. Parasitol. 59 151-160. [Pg.84]

Robertson, C. D. and Coombs, G. H. (1993) Cathepsin B-like cysteine proteases of Leishmania mexicana. Mol. Biochem. Parasitol 62 271 280. [Pg.86]

Hassan, H. F. and Coombs, G. H. (1985) Purine phosphoribosyltransferases of Leishmania mexicana mexicana and other flagellate protozoa. Comp. Biochem. Physiol. [B] 82 113-119. [Pg.114]

Fong, D., Wallach, M., Keithly, J., Melera, P. W. and Chang, K. P. (1984) Differential expression of mRNAs for alpha- and beta-tubulin during differentiation of the parasitic protozoan Leishmania mexicana. Proc. Natl. Acad. Sci. USA 81 5782-5786. [Pg.252]

Rabinovitch, M., Topper, G., Cristello, P. and Rich, A. (1985) Receptor-mediated entry of peroxidases into the parasitophorous vacuole of macrophages infected with Leishmania mexicana amazonensis. J. Leuk. Biol. 31 247-261. [Pg.320]

Lambeir, A.M., Backmann, J., Ruiz-Sanz, J., Filimonov, V, Nielsen, J.E., Kursula, I., Norledge, B.V., Wierenga, R.K. The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase. Fur. J. Biochem. 2000, 267, 2516-24. [Pg.105]

Garami A, Mehlert A, Ilg T. Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dohchol phosphate-man-nose synthase gene deletion mutants. Mol Cell Biol 2001 21 8168-8183. [Pg.107]

Detke S, Chaudhuri G, Kink JA et al. DNA amplification in tunicamycin-resistant Leishmania mexicana. Multicopies of a single 63-kilobase supercoiled molecule and their expression. J Biol... [Pg.6]

Lee ST, Liu HY, Lee SP et al. Sdection for arsenite resistance causes reversible changes in minicirde composition and kinetoplast oi anization in Leishmania mexicana. Mol Cdl Biol 1994 14 587-596. [Pg.8]

Lu HG, Zhong L, Chai KP et al. Intracellular Ca pool content and signaling and expression of a calcium pump are linked to virulence in Leishmania mexicana amazonensis amast otes. J Biol Chem 1997 272 9464-9473. [Pg.31]

Burchmore RJS, Hart DT. Glucose transport in promasdgotes and amastigotes of Leishmania mexicana Characterization and comparison with host ucose transporters. Mol Biochem Parasitol 1995 74 77-86. [Pg.32]

Hart DT, Coombs GH. Leishmania mexicana Energy metabolism of amastigotes and promast tes. Exp Parasitol 1982 54 397-409. [Pg.32]

Burchmore RJS, Landfear SM. Differential regulation of multiple glucose transporter genes in the parasitic protozoan Leishmania mexicana. J Biol Chem 1998 273 29118-29126. [Pg.32]

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