Leishmania braziliensis

The pentavalent antimony compound, sodium stibogluconate, is used as an anti-parasitic drug. Treatment of Leishmania braziliensis has been reported to be successful with sodium stibogluconate whereas in Leishmania mexicana, the response was lower and the preferred drug for this disease was ketoconazole . 

In a prospective, open trial, conventional treatment with sodium stibogluconate (n = 69) was compared with meglumine antimoniate (n = 58) for cutaneous Leishmania braziliensis (13). The trial was too small and of too short a duration to compare efficacy rehably, but... 

Berberine and 8-cyanodihydroberberine were found to exhibit significant activity (> 50% suppression of lesion size) against the lesions of Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine (canadine) was more potent but less toxic than berberine against Leishmania donovani, but not as potent as meglumine antimonate, a standard drug utilized in the therapy of leishmaniasis [209]. 

In the adult, both the cutaneous and mucocutaneous forms of leishmaniasis [Leishmania braziliensis and L. mexicana) are treated with stibogluconate. An alternative drug for the visceral form is amphotericin B. 

Leishmania braziliensis Leishmaniasis Differentiation of cutaneous and sylvatic types L4... 

L4. Lopez, M., Orrego, C., Cangalaya, M. A., Inga, R. M., and Arevalo, J. L., Detection of Leishmania braziliensis from minimally processed human biopsies via the polymerase chain reaction (PCR). Abstr. Am. Soc. Microbiol., May 13-17 (1990). 

A series of monomeric and dimeric naphthoquinones with potential for treatment of Leishmania infections were identified in vitro using a direct cytotoxicity assay against extracellular promastigotes of Leishmania spp. [196,197]. Lapachol was evaluated in vitro against intracellular amastigotes of Leishmania braziliensis and then tested in an animal model (hamster) to try to reproduce the leishmanicidal activity. In vitro lapachol exhibited an... 

Darling, T. N., Davis, D. G., London, R. E. and Blum, J. J. (1987) Products of Leishmania braziliensis glucose metabolism release of D-lactate and, under anaerobic conditions, glycerol. Proc. Natl. Acad. Sci. USA 84 7129-7133. 

Keegan, F. P., Sansone, L. and Blum, J. J. (1987) Oxidation of glucose, ribose, alanine and glutamate by Leishmania braziliensis panamensis. J. Protozool. 34 174-179. 

Marr, J. J., Berens, R. L. and Nelson, D. J. (1978) Purine metabolism in Leishmania donovani and Leishmania braziliensis. Biochim. Biophys. Acta 544 360-371. 

Follador I, Araujo C, Bacellar O et al. Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection. Clin Infect Dis 2002 34(ll) E54-8. 

Nelson DJ, Bu e CJ, Elion GB et al. Metabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani Allopurinol, oxipiuinol, and 4-aminopyrazolo(3,4-d)pyiimidine. J Biol Chem 1979 254(10) 3959-3964. 

Amoeba chaos chaos, 20°C A. chaos chaos, 25°C A. chaos chaos, 30°C Astasia klebsii, young, 25.2°C Chilomonas paramecium, 25°C Leishmania braziliensis, 32 °C Leptomonas ctenocephali, 28°C Paramecium aurelia, 20°C P aurelia, 25°C P aurelia, 35°C P caudatum, 20°C P caudatum, 25°C P. multimicronucleatum, 25°C Plasmodium cathemerium, 38°C P. knowlesi, 38°C Strigomonas fasciculata, 28°C... 

Population growth kinetics of promastigotes of Leishmania braziliensis (LB) exposed to samples of vulcanized NR and NR/NZF nanocomposites with different concentrations of nanoparticles. 

In this section NR membranes with colloidal incorporation of gold nanoparticles are used, synthesized by an in situ method (NR/Au) at different reduction times, in order to evaluate the physiological behaviour of Leishmania braziliensis promastigotes cultured in axenic medium, in a colony of 7 weeks old, evaluating the increase in kinetics in relation to the permanence time of the membranes in the culture medium as a function of reduction time and temperature of preparations of NR membranes. 

Antiprotozoan - in vitro against Leishmania braziliensis and L. donovani at 10.0 gg/mL. 116... 

I. D. Velez, L. M. Carrillo, L. Lopez, E. Rodriguez, and S. M. Robledo, An epidemic outbreak of canine cutaneous leishmaniasis in Colombia caused by Leishmania braziliensis and Leishmania panamensis, American Journal of Tropical Medicine and Hygiene, 86, 807-811, 2012. 

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