Lectins galectin

General Considerations Cell-surface Carbohydrate Recognition Interactions 11.1.3.1 S-type Lectins, Galectins... 

Fig. 11.1-2 (a) Structure of S-type lectin, galectin-3, bound to /V-acetyllactosamine and... 

L. He, S. Andre, H.-C. Siebert, H. Helmholz, B. Niemeyer, and H.-J. Gabius, Detection of ligand- and solvent-induced shape alterations of cell-growth-regulatory human lectin galectin-1 in solution by small angle neutron and x-ray scattering, Biophys. J., 85 (2003) 511-524. 

Gal-specific lectins Galectin, animals Signaling, cell adhesion D-Lactulosamines 358... 

Fradin C, Poulain D, Jouault T. beta-I,2-linked oligomannosidcs from Candida albicans bind to a 32-kilodalton macrophage membrane protein homologous to the mammalian lectin galectin-3. Infect Immun 2000 68 43914398. 

K. N. Konstantinov, B. A. Robbins, and F.-T. Liu, Galectin-3, a /l-galactoside-binding animal lectin, is a marker of anaplastic large-cell lymphoma, Am. J. Path., 148 (1996) 25-30. 

The deprotected lactosides were evaluated as inhibitors against lectin binding in a solid-phase inhibition assay with immobilized ASF on the surface of microtiter plate wells, mimicking cell-surface presentation, while mammalian galectins-1, -3, and -5 were in solution. Strong multivalency effects and selectivity were observed for the... 

Glycan array allows for the definition of fine differences in specificity among related lectins giving clues about the basis for differences in their biological activities. For example comparison of a set of human galectins demonstrated that Gal-1, Gal-2, and Gal-3 all bind /V-acetyllactosamine but... 

A number of carbohydrate recognition domains (CRDs) of animal lectins are known to exist as clusters. ASGP-Rs exist as bundle of hexamers, mannose 6-phosphate receptor and galectin-3 are known as dimers, while mannose binding proteins and receptors form multiple CRDs [31]. 

A review of the genomic evidence for the conservation of the galectins, a family of lectins. 

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