Macrophage membrane

Ramprasad, M.P., Fischer, W., Witztum, J.L., Sambrano, G.R., Quehenberger, O., and Steinberg, D., 1995, The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphatidylserine-rich liposomes is identical to macrosiaUn, the mouse homologue of human CD68, Proc. Natl. Acad. Sci. U.S.A. 92 9580-9584. 

Martinez-Pomares, L., Platt, N., McKnight, A.J., da Silva, R.P., and Gordon, S., 1996, Macrophage membrane molecules markers of tissue differentiation and heterogeneity. Immunobiology 195 407-416. 

Gallagher, J.E. George, G. Brody, A.R. Sialic acid mediates the initial binding of positively charged inorganic particles to alveolar macrophage membranes. Am. Rev. Respir. Dis. 1987, 135, 1345-1352. 

Roche AC, Midoux P, Pimpancau V, et al. Endocytosis mediated by monocyte and macrophage membrane lectins—application to antiviral drag targeting. Res Virol 1990 141 243-249. 

J774 macrophage membranes 2-Arach ido noyl glycerol 110 Di Marzo etal. 1999... 

Since MGL is a serine hydrolase, its sensitivity to many of the available serine hydrolase inhibitors has been explored (Table 3). The results support the hypothesis that MGL can be inhibited by compounds that interact with its reactive serine. On the other hand, the potencies of the inhibitors are quite variable in some cases, this likely reflects differences in assay methodology (i.e., substrate concentration, pH, form of the enzyme). However, in a few cases, the same assay conditions revealed very different inhibitory potencies (e.g., compare the platelet and macrophage membrane studies by Di Marzo et al. 1999). In any event, studies of these compounds are not likely to yield selective inhibitors of MGL. All of these compounds are inhibitors of FAAH (see above) and many are also inhibitors of PLA2, diacylglycerol lipase, and acetylcholine esterase, among other hydrolases. By analogy to the development of the URB series of FAAH inhibitors (Kathuria et al. 2003), it is likely that selective inhibitors of MGL will come from other synthetic avenues. 

Krugluger, W., Lucas, T., Koller, M., Boltz-Nitulescu, G., and Froster, O. (1996) Soybean Agglutinin Binds a 160-kDa Rat Macrophage Membrane Glycoprotein and Enhances Cell Differentiation and Activation, Immunol. Lett. 52,53-56. 

Fig. 1. Schematic representation of the possible reactions of the immune system to drugs. A drug is probably presented as antigen most efficiently after binding to macrophage membranes and interacting with T-helper lymphocytes, which may either generate effector-sensitized T-lymphocytes or cooperate with B-l3miphocytes in the production of antidrug antibodies. This scheme of T/B cooperation is extremely oversimplified, since the various circuits of T-helper and suppressor cells are not represented (Germain et al. 1981)...

Fradin C, Poulain D, Jouault T. beta-I,2-linked oligomannosidcs from Candida albicans bind to a 32-kilodalton macrophage membrane protein homologous to the mammalian lectin galectin-3. Infect Immun 2000 68 43914398. 

References (21-23) describe time-resolved fluorescence anisotropy studies (using TMA-DPH and DPH as fluorescent probes), of the effect of immime complexes on macrophage membrane fluidity, the effect of succinate and phenyl succinate on the fluidity of the inner mitochondrial membrane, and the role of cholesterol in modulating the fluidity of renal cortical brush border and basolatered membranes, respectively. 

Jakab GJ, Risby TH, Sehnert SS, Hmieleski RB, Gilmour MI. Suppression of alveolar macrophage membrane receptor-mediated phagocytosis by model particle adsorbate complexes physico-chemical moderators of uptake. Environ Health Perspect 1991 89 169-174. 

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