High-throughput screening lead discovery process

Alanine, A., Nettekoven, M., Roberts, E., and Thoma, A.W. Lead generation - enhancing the success of dmg discovery by investing in the hit to lead process. Comb. Chem. High Throughput Screen. 2003, 6, 51-66. 

After the hit discovery process (often using high-throughput screening), early drug discovery is generally split into a hit to lead phase and a lead optimization phase, followed by the selection of development candidates (DCs) (Figure 12.2). In vitro... 

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