Laser-induced acoustic desorption/electrospray ionization mass spectrometry

Cheng, S.C., Huang, M.Z., Shiea, J. (2009) Thin-layer chromatography/laser-induced acoustic desorption/ electrospray ionization mass spectrometry. Analytical Chemistry, 81, 9274-9281. [Pg.1203]

Laser-induced acoustic desorption-electrospray ionization mass spectrometry (LlAD-ESl/MS) is a technique combining an electrospray and a pulsed laser beam to characterize solid and liquid samples with minimal sample preparation [48]. Although the instrumental setup of LIAD-ESl is similar to that of ELDl, the laser intensity required for LIAD (i.e., 10 W/cm ) is higher than that for ELDl, and the desorption mechanism of LIAD is also different from that of LD. In LIAD, the sample is not desorbed by direct laser irradiation, but by acoustic and shock waves induced by the laser irradiation. A pulsed laser beam with a flux energy of several mJ is used to irradiate the rear of a thin metal foil (e.g., AL Ti, Cu, and Ta 5-25 pm thickness) to generate acoustic and shock waves [48-50]. These laser-induced... [Pg.114]

Chapter 6, titled Selection of Ionization Methods of Analytes in the TLC-MS Techniques provides an overview of mass spectrometric techniques that can be coupled with TLC and act as specific detectors in this hyphenated approach. The mass spectrometric techniques discussed in this chapter are secondary mass spectrometry (SIMS), liquid secondary ion mass spectrometry (LSIMS), fast atom bombardment (FAB), matrix-assisted laser desorption/ionization (MALDI), atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI), electrospray ionization (ESI), desorption electrospray ionization (DESI), electrospry-assisted laser desorption/ionization (ELDI), easy ambient sonic spray ionization (EASI), direct analysis in real time (DART), laser-induced acoustic desorption/electrospray ionization (LIAD/ESI), plasma-assisted multiwavelength laser desorption/ionization (PAMLDI), atmospheric-pressure chemical ionization (APCI), and dielectric barrier discharge ionization (DBDI). For the sake of illustration, the authors introduce practical examples of implementing TLC separations with detection carried out by means of individual mass spectrometric techniques for the systematically arranged compounds belonging to different chemical classes. [Pg.9]