Lactic acid buildup

Problem 9.25 Lactic acid buildup in tired muscles results from reduction of pyruvate. If the reaction occurs from the Re face, what is the stereochemistry of the product ... 

Conditions that cause decreased oxygenation of tissues force excessive dependence on anaerobic glycolysis for energy production, with attendant lactic acid buildup in tissues and spiiiover into the biood. 

Why does weightlifting produce lactic acid buildup in... 

Runners risk suffering from lactic acid buildup. 

As previously mmtioned, hydrazine sulfate has been said to inhibit the eonver-sion of lactic acid back to glucose. A more direct way to break the cycle would be the inhibition or negation of the conversion of glucose to lactic add in the first place, for a lactic acid buildup in the blood can in itself be bad news. 

Allen, D., and H. Westerblad. Lactic Acid—The Latest Performance-Enhancing Drug. Sdercce305, 1112 — 1113 (2004). [An article refuting certain assumptions about lactic acid buildup and muscle fatigue]. 

Going for the burn in a workout refers to the sensation that accompanies lactic acid buildup. This in turn arises from anaerobic metabolism of glucose in muscle. 

In animals, lactic acid is transported out of the muscles to the liver, where it is reconverted into glucose or amino acids. Lactic acid buildup is a source of the muscle stiffness that occurs after vigorous exercise. In yeast, pyruvate is converted to acetaldehyde and CO2 then the acetaldehyde is reduced to ethanol. 

Adverse reaction to Glucophage is lactic acid buildup, not stroke. 

Conditions that result in increased production of metabolic acids include lactic acidosis and diabetic ketoacidosis. Lactic acidosis occurs with anaerobic metaboUsm in the presence of severe hypoxemia (i.e., Pao < 36 mm Hg). Any condition that prevents adequate oxygenation resulting in hypoxemia, such as respiratory failure or lung cancer, as well as any condition causing a decrease in perfusion to body tissues, such as heart failure or shock of any form, will result in anaerobic metabolism and lactic acid buildup. In diabetic ketoacidosis, the lack of insulin to move glucose into the cells results in a form of starvation and the production and accumulation of ketoacids (i.e., ketosis) owing to the use of lipids for fuel. 

The combined effects of oxygen debt and lactic acid buildup in muscles the aftermath of the the women s 3000m Steeplechase at the London 2012 Olympic Games. 

Lactic acidosis (buildup of lactic acid in the blood) may also occur with die administration of metformin. Although lactic acidosis is a rare adverse reaction, its occurrence is serious and can be fatal. Lactic acidosis occurs mainly in patients with kidney dysfunction. Symptoms of lactic acidosis include malaise (vague feeling of bodily discomfort), abdominal pain, rapid respirations, shortness of breath, and muscular pain. In some patients vitamin B12 levels are decreased. This can be reversed with vitamin B12 supplements or with discontinuation of the drug therapy. Because... 

During strenous exercise there is little oxygen, 02, available for muscle cells. Under these conditions, the muscle cells derive most of their energy from the anaerobic conversion of pyruvic acid, C3H403, into lactic acid, C3H603. The buildup of lactic acid makes the muscles ache and fatigue quickly. Is the pyruvic acid oxidized or reduced as it transforms into lactic acid ... 

Although angina pectoris is believed to be caused by the buildup of lactic acid and other metabolites, the exact mechanisms responsible for mediating anginal pain remain unknown. Also, the emotional state of the patient and other factors that influence central pain perception play an obvious role in angina pectoris.20,34 In fact, the majority of anginal attacks may be silent in many patients, and myocardial ischemia may ffe-... 

O Muscle soreness from physical activity is caused by a buildup of lactic acid in muscle tissue. Analysis of lactic acid reveals it to be 40.0% carbon, 6.71% hydrogen, and 53.3% oxygen by mass. Calculate the empirical formula of lactic acid. 

C. Main Powerhouse. There is buildup of pyruvate and lactic acid. 

This same sequence of reactions, up to the formation of pyruvic acid, occurs in the human body in times of stress when energy is needed, but not enough oxygen is available for normal aerobic oxidation. The pyruvic acid under these conditions is converted to lactic acid. It is the buildup of lactic acid in the muscles that is partly responsible for the feeling of fatigue. 

The lactic acid that is produced is moved from the muscles through the blood to the liver. There, it is converted back into glucose that can be used in catabolic processes to yield more energy once oxygen becomes available. However, if lactic acid builds up in muscle cells at a faster rate than the blood can remove it, muscle fatigue results. Buildup of lactic acid is what causes a burning pain in the muscle during strenuous exercise. 

Sometimes people get sore muscles from a buildup of lactic acid in their muscles. Milk that spoils also makes lactic acid. 

After exercise, muscles sometimes become sore because of a buildup of lactic acid. How might this buildup temporarily affect the acid-base balance in the blood ... 

Almost all cross-flow filtration processes are inherently susceptible to flux decline due to membrane fouling (a time-dependent phenomenon) and concentration polarization effects which reflect concentration buildup on the membrane surface. This means lower flux (i.e., product output) which could drive the capital costs higher due to the requirement of a larger surface area to realize the desired production rate. In some situations, the lower flux could also result in lower selectivity which means reduced recoveries and/or incomplete removal of impurities from the filtrate. For example, removal of inhibitory metabolites such as lactic acid bacterial or separation of cells from broth while maximizing recovery of soluble products. 1 1... 

By virtue of what is called the law of mass action, the buildup of product itself works against the conversion reaction. Thus, the very buildup of lactic acid or lactate product serves as an inhibitor. (Albeit pyruvic acid is also listed as an inhibitor in the compilations, but which is a reactant for the conversion to lactic acid.) Another inhibitor listed is oxalic acid, a naturally occurring component of such vegetables as spinach and rhubarb, and which becomes toxic in large amounts. The common... 

Strenuous exercise causes a buildup of lactic acid in muscle tissues. 

Recall If lactic acid is the buildup product of strenuous muscle activity, why is sodium lactate often given to hospital patients intravenously ... 

The bubbles in beer are COg, produced by alcohoUc fermentation. Tired and aching muscles are caused in part by a buildup of lactic acid, a product of anaerobic glycolysis. 

Anyone who goes from a long period of inactivity to vigorous exercise (for example, from months of watching television to several hours of racquetball) experiences stiffness due to the buildup of lactic acid in the tissues. Even during moderate exercise, muscle activity generates the weak acid carbon dioxide. For example, if glucose is oxidized to water and carbon dioxide and the enzyme carbonic anhydrase interconverts CO2 and carbonic acid ... 

A The buildup of lactic acid in muscles causes pain during extreme physical exertion. The for lactic acid, C2HSOCOOH, is 8.4 X 10 A Calculate the pH of a 0.110 M solution of lactic acid. Can you make a simphlying assumption in this case ... 

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