L-1210 leukemia cell

ATP synthesis was inhibited 30-40% in A431 cells at lpg/ml 38a This inhibition was stronger than than observed for 37 or 38. Growth of A431 cells was strongly inhibited at 1 pg/ml 38a this effect was reversible. Ehrlich carcinoma cells grown in mice were 50% inhibited by 38a (0.5 mg/kg, i.p., daily for 9 days). No antitumor effect was observed for 38a (0.5 mg/kg) with P388 cells, or L-1210 leukemia cells in mice. Piericidin B( A-oxide was found to be toxic to mice at lmg/kg [153],... 

Our application is to mouse L-1210 leukemia cells where it is observed experimentally that essentially exponential growth occurs during the main middle portion of cell growth (see Reference 16). An asymptotic solution for this case can be developed by assuming a functional form ... 

The corresponding 5-methyluracil analog, l-(2 -deory-2 -fluoro-p-D-arabinofnranosyl)-5-methyluracil [FMAU] was found to be more potent in mice infected with Herpes simplex vims (HSV) types 1 and 2 without toxicity at effective dose levels. FMAU was also found to be active in vitro and in vivo against P-815 and L-1210 leukemia cell lines resistant to the antileukemic agent, 1-p-D-arabinofnranosyl-cytosine [Ara-C]. A Phase 1 trial of FMAU in patients with advanced cancer showed that drug-induced central nervous system (CNS) dysfunction was the dose-limiting toxicity (J). 

Mercaptonurine - 5-Formamide-l-B-ribofuranosylthioimidazole-4-carboxamide 2, 3, 5 -triformate, is comparable with 6-mercaptopurine (6-MP) for the treatment of leukemias.33 it is cross-resistant with 6-MP. Conversion of 6-MP ribonucleoside to 6-MeMP ribonucleotide has been shown in L-1210 leukemia cells, adenocarcinoma 755 cells, H. Ep. No. 2 cells and other systems. 6-MeMP ribonucleotide is responsible for the inhibition of purine synthesis produced by 6-MP.3 Metabolism of 6-MeMP in Ehrlich ascites cells has been studied.Breakdown of the active nucleotide form of the 6-thlopurines by alkaline phosphohydrolase is probably responsible... 

Ursolic acid was isolated from the fruiting spikes using bioassay-directed fractionation. It showed significant cytotoxicity against P-388 and L-1210 leukemia cells and A-549 human lung carcinoma cells, and marginal cytotoxicity in KB, HCT-8 human colon, and MCF-7 mammary tumor cells (86),... 

Colabomycin A (51) has been isolated from the mycelium of Streptomyces griseoflavus (strain Tii 2880) [109], and is active against Gram-positive bacteria and L-1210 leukemia stem cells. 

The anticancer activity of the bromocompound aeroplysinin-1 (4) and the dienone (1) is more interesting. Both compounds were active in the KB cells test and aeroplysinin-1 (4) revealed L-1210 Leukemia activity in mice. 

In this communication we extend our earlier observations, which primarily dealt with the antiviral action of mouse fibroblast interferon, to its antigrowth activity and to antiviral and antigrowth activities of mouse T-cell interferon. We will show that inhibition by common gangiiosides Is restricted to both activities of fibroblast interferon alone. T-cell interferon, although its biological activities are analogous to those of fibroblast Interferon, neither binds to nor Is inhibited by these glycol ipids. Furthermore we demonstrate that mouse leukemia L—1210 cells that were selected for resistance to fibroblast interferon (6), respond equally well to T-cell Interferon as the parent cells which are responsive to both Interferons. 

N3P3Az2(NHMe)4 for mice amounts to 50 mg kg The antitumor effect of this compound on leukemia L 1210 cells in mice expressed as TIC value (r is the mean life span of treated mice C is the mean life span of control mice) is 200% for a dose equal to 30 mg kg" with 25% long term survivors. ... 

Effects of Cephalotaxine Esters on HL-60 Leukemia Cell Differentiation and Inhibition of L-1210 In Vrntd ... 

Table 1. (cont.) In vitro cytotoxicity of marine [3-carboline and isoquinoline alkaloids against P-388 and L-1210 murine leukemias, KB human nasopharyngeal carcinoma, A-459 non-small cell lung carcinoma and other cell lines, (IC50, pg/mL). ... 

L-1210 and P388 - murine leukemia cells L5178 - mouse lymphoma cells KB - human nasopharyngeal cells A-549 - lung carcinoma cells... 

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