Streptomyces griseoflavus

Reduction of aromatic nitro compounds by sulfide catalyzed by extracellular compounds excreted into the medium during growth of Streptomyces griseoflavus (Glaus et al. 1992). 

Isolated from Streptomyces griseoflavus strain W384... 

SCF, Saccharomyces cerevisiae ade2, forward mutation SCF, Saccharomyces cerevisiae ade2, forward mutation SGR, Streptomyces griseoflavus, reverse mutation ANR, Aspergillus chevalieres. reverse mutation NCF, Neurospora crassa, forward mutation NCR, Neurospora crassa, reverse mutation NCR, Neurospora crassa, reverse mutation DMX, Drosophila melanogaster, sex-linked recessive lethal... 

Colabomycin A (51) has been isolated from the mycelium of Streptomyces griseoflavus (strain Tii 2880) [109], and is active against Gram-positive bacteria and L-1210 leukemia stem cells. 

Streptomyces griseoflavus var. pyrindicus Pyrindicin (96), a compound possessing weak antimicrobial activity, has been isolated from the culture broth of this variant of Streptomyces griseoflavus. ... 

Pyrindicin.—The pattern of C n.m.r. signal enhancement observed on incorporation of [1- C]- and [2- C]-acetate and [l- C]propionate into pyrindicin (9) in Streptomyces griseoflavus var. pyrindicus indicates that the metabolite is formed from five acetate units and one propionate unit, as shown in (9). Some labelling by acetate of the propionate unit was observed, which was interpreted as being the result of metabolism via both the tricarboxylic acid and glyoxalate cycles. 

Okilactomycin was isolated by Imai and associates in 1987 it is an architecturally complex polyketide antitumor antibiotic derived from a bioactive filtrate produced by the actinomycetes, Streptomyces griseoflavus, obtained from a soil sample on the island of Zamami, Okinawa, Japan. (+)-Okilactomycin exhibits significant in vitro cytotoxicity when assayed against a number of human cancer cell lines, including lymphoid leukemia L1210 and leukemia P388... 

Bickel, H., E. Vischer, A. Wettstein, and H. Zahner Acumycin, a new antibiotic produced by Streptomyces griseoflavus. Gazz. chim. ital. 93, 130 (1963). 

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