Kit ligand

Costa JJ, Demetri GD, Harris TJ. Dvorak AM. Hayes DF, Merica EA, Menchaca DM. Gringeri AJ. Schwartz LB, Galli SJ Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med 1996 183 2681-2686. 

Zsebo KM, Metcalfe DD. Geissler EN. Galli SJ Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem dS cell factor. Proc Natl Acad Sci USA 1991 88 6382. 

Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis. N Engl J Med 1993 328 1302-1307. 

Heissig B, Hattori K, Dias S, et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 2002 109(5) 625-637. 

Besmer, P. (1991). The kit ligand encoded at the murine Steel locus a pleiotropic growth and differentiation factor. Curr. Opin. Cell Biol. 3 939-946. 

Flanagan, J. G and Leder, P. (1990). The kit ligand a cell surface molecule altered in Steel mutant fibroblasts. Cell 63 185-194. 

Flanagan, J. G Chan, D. C., and Leder, P. (1991). Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sf mutant. Cell 64 1025-1035. 

Marziali, G., Lazzaro, D., and Sorrentino, V. (1993). Binding of germ cells to mutant Sld Sertoli cells is defective and is rescued by expression of the transmembrane form of c-kit ligand. Dev. Biol. 157 182-190. 

Tajima, Y Onoue, H Kitamura, Y., and Nishimune, Y. (1991). Biologically active kit ligand growth factor is produced by mouse Sertoli cells and is defective in Sid mutant mice. Development 113 1031-1035. 

Steel, K. P., Davidson, D. R., and Jackson, I. J. (1992). TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor. Development 7/5 1111-1119. 

Carson W-E, Fehniger TA, Caligiuri MA CDSe " natural killer cell subsets characterization of distinct functional responses to interleukin-2 and the c-kit ligand. Fur J Immunol 1997 27 354-360. 

Approach taken to further understanding osteopetrosis was based on knowledge concerning two phenolypically similar murine mutants with macrocytic anemia (Wiktor-Jedrzejczak et al., 1981). These two anemias one secondary to mutation of the W locus (now known as c-kit) and the other secondary to the mutation of Steel locus (now known as gene for Kit Ligand or Steel Factor) are reciprocally sensitive/resistant to bone marrow transplantation... 

Stem cell factor kit ligand steel factor SCF... 

Proteolytic processing of membrane-anchored proteins is an important event. TNE-a, TGF-(x, EGF, heparin-binding EGF-like growth factor (HB-EGF), the Kit ligand, and other growth factors must all be processed to become functional. Processing has other... 

IL-3 is produced by T lymphocytes, but also by mast cells. In rodents it is important for the development of mast cells and basophils and promotes eosinophil survival (Wasserman, 1990). Antibodies to IL-3 result in a fall in tissue numbers of mast cells in mice. IL-3 has been repotted to protect mast cells from apoptosis, an event likely mediated by the maintenance of intracellular calcium levels (Mekori et al., 1993). Whether IL-3 plays a critical role in mast cell expression in human tissues is not clear and other cytokines including IL-10 and stem cell ffictor c-kit ligand) may also be important. 

Packer Al, Besmer P Bachvarova RF. 1995. Kit ligand mediates survival of type A spermatogonia and dividing spermatocytes in postnatal mouse testes. Mol. Re prod. Dev. 42 303-10... 

B. Heissig, Z. Werb, S. Rafii, and K. Hattori, Role of c-kit/Kit ligand signaling in regulating vasculogen-esis, Thromb Haemost 90, 570-576 (2003). 

Bankl HC, Radaszkiewicz T, Klappacher GW, Glogar D, Sperr WR, Grossschmidt K, Bankl H, Lechner K, Valent P Increase and redistribution of cardiac mast cells in auricular thrombosis. Possible role of kit ligand. Circulation 1995 91 275-283. 

Schuening FG, Appelbaum FR, Deeg HJ etal. (1993). Effects of recombinant canine stem cell factor, a c-kit ligand, and recombinant granulocyte colony stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation. Blood, 81, 20-26. 

Duttlinger, R., Manova, K., Chu, T.Y., Gyssler, C., Zelenetz, A.D., Bachvarova, R.F. and Besmer, P. (1993) W-sash affects positive and negative elements controlling c-kit expression ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis. Development 118 705-717. 

S ATP -h phosphatidylinositol 3-kinase <57> (<57>, binding of c-kit ligand, stem cell factor SCF to c-kit receptor c-kitR is known to activate c-kitR tyrosine kinase, thereby leading to autophosphorylation of c-kitR on Tyr and to association of c-kitR with substrates such as phosphatidylinositol 3-kinase [172]) (Reversibility <57> [172]) [172]... 

---