Kidney tumors metastatic

Pitfalls in the diagnosis of WT versus other kidney tumors include primary renal EWS/PNET, small cell synovial sarcoma, leukemia/lymphoma, and metastatic alveolar RMS. 

Extraluminal infection and/or abscess formation can occur at any site after any of the other syndromes or may be the primary presentation. Metastatic infections have been reported to involve bone, cysts, heart, kidney, liver, lungs, pericardium, spleen, and tumors. 

In humans, also, preferential sites exist for the formation of metastasis from various primary tumors [reviewed in Zetter (Zl)]. Thus, bone is a preferred site for metastasis from primary malignancies in breast, prostate, and kidney, while liver is a frequent metastatic site for tumors originating in the colon. Different types of leukemias vary widely in their ability to spread to liver, lymph, bone, and spleen. Some organs, however, are rarely colonized by metastatic growth. These resistant sites include skeletal muscle, heart, and skin. 

This digestion, isolation, and storage approach has been successfully applied to a wide range of tumor and normal tissues. Tumor tissues include both primary and metastatic tumors of the more common types, such as colon, lung, and ovarian tumors, melanomas, and sarcomas, and rare tumors, such as schwannoma. Normal cell populations include lung, ovary, colon, heart, liver, kidney, and blood. 

Therapeutic applications Cisplatin has found wide application in the treatment of solid tumors such as metastatic testicular carcinoma in combination with vinblastine (see p. 390) and bleomycin (see p. 386), ovarian carcinoma in combination with cyclophosphamide (see p. 388), or alone for bladder carcinoma. Carboplatin is employed when patients cannot be vigorously hydrated as is required for cisplatin treatment, or if they suffer from kidney dysfunction or are prone to neuro- or ototoxicity. 

Osteolytic tumors may induce bone destruction either through local invasion, or by a secondary metastatic bone disease. The most frequent types of primary tumors that develop into metastatic bone disease are, in the order of prevalence breast, prostate, thyroid, kidney, and bronchial tumors, whereas esophageal, gastrointestinal and rectal tumors are much less metastatic [11]. Very often, the destruction of bone in a metastatic bone disease leads to hypercalcemia of malignancy, which also responds to BPs. In addition, hematological cancers such as... 

The main difficulties lie in the differentiation of adrenal cortical tumors from adrenal medullary tumors, namely, pheochromocytomas, and the differentiation of adrenal tumors from extra-adrenal tumors (i.e., metastatic carcinomas or primary carcinomas of neighboring structures such as the kidney or liver) (Fig. 10.30). 

Tominaga Y, Tsuzuki T, Matsuoka A, et al. Expression of parafibromin in distant metastatic parathyroid tumors in patients with advanced secondary hyperparathyroidism due to chronic kidney disease. World J Surg. 2008 32 815-821. 

In hospitalized patients, hypercalcemia of malignancy is the major cause of hypercalcemia (26,, , 54). In two separate studies, 9X of all cancer patients had hypercalcemia of malignancy (. 56). Hypercalcemia of malignancy is most common in solid tumors such as carcinomas of the lung, breast, kidney, pancreas and ovary, but also occurs with multiple myeloma and adult T-cell lymphoma/ leukemia. It has been estimated that there is approximately an equal distribution between humoral factors and metastatic bone tumors for causing hypercalcemia of malignancy (26,57,58). 

Oncophage (vitespen) is a vaccine that contains gp96 heat shock protein/peptide complex from an individual patient s tumor. It has been evaluated in phase III trials for kidney cancer and metastatic melanoma. 

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