K. pneumoniae

Hydrogen was introduced into a standard hydrogenation vessel containing 10 grams 6-deoxy-6-demethyl-6-methylene-5-oxytetracycline hydrochloride (methacycline), 150 ml methanol and 5 grams 5% rhodium on carbon. The pressure was maintained at 50 psi while agitating at room temperature for 24 hours. The catalyst was then filtered off, the cake washed with methanol and the combined filtrates were evaporated to dryness. The dry solids were slurried in ether, filtered and the cake dried. The resulting solids exhibited a bioactivity of 1,345 units per mg versus K. pneumoniae. 

Class A Serine p-lactamases SHV-1 penicillinase in K. pneumoniae, and Koxy with activity against certain third generation cephalosporins in K. oxytoca BlaZ staphylococcal penicillinase TEM, SHV, VEB, PER and CTX-M penicillinases and ESBLs (P-lactamases with activity against third generation cephalosporins and aztreo-nam) KPC, IMI/NMC and SME carbapenemases... 

Tributyltin(IV) derivatives of six different pharmaceutically active carboxylates were synthesized and their antibacterial activities were tested using 10 different bacteria (B. cereus, C. diphtheria, E. C. ETEC, K. pneumonia, P. mirabilis, P. aeroginosa,... 

Extensive screening methodology was used to find the suitable microorganism. As a result, K. pneumoniae IFO 3319 out of 450 bacterial strains was found to give the corresponding (2J, 3S)-hydroxy ester with 99% de and >99% ee in kilogram scale quantitatively [29g]. 

The purified preparations of the apo-MoFe proteins from both organisms included a small additional polypeptide of around 20 kDa. This was shown to be the nifY product in K. pneumoniae (94) and a non-nif protein denoted y in A. vinelandii (95). These proteins are apparently essential for effective reaction with FeMoco and are associated with the MoFe protein polypeptide through its interaction with the Fe protein and MgATP (96, 97) (see Section IV,C,3). These observations demonstrate a third role for the Fe protein in generating a form of apo-MoFe protein that is capable of accepting FeMoco. 

A further important discovery has resulted from studies on complex formation (114). With K. pneumoniae nitrogenase it has been shown that the MoFe protein containing a full complement of metal is com-... 

Table 13 Comparison of E. coli and K. pneumoniae subsp, aerogenes...

The last class, represented by E. coli 11 , consists of a membrane domain involving two distinct peptides, one very hydrophobic, and one somewhat less hydrophobic. The domains A and B are not covalently attached to the membrane domains but are separate cytoplasmic proteins [25,107], Other representatives of this class include B. subtilis [26] and K. pneumoniae II " [8],... 

The degradation of DDT by organisms designated Aerobacter aerogenes (possibly Klebsiella aerogenes) (Wedemeyer 1967) (Figure 2.6), and the partial reductive dechlorination of methoxychlor by K. pneumoniae (Baarschers et al. 1982). 

The biotransformation of methyl phenyl phosphonate to benzene by K. pneumoniae (Cook et al. 1979) (Figure 2.7a). Further examples of the cleavage of the carbon-phosphorus... 

The biotransformation of 3,5-dibromo-4-hydroxybenzonitrile to the corresponding acid by a strain of K. pneumoniae ssp. ozaenae which uses the substrate as sole source of nitrogen (Figure 2.7c) (McBride et al. 1986). 

Utilization of nric acid as a nitrogen source by strains of Aer. aerogenes, K. pneumoniae, and Serratia kiliensis (Ronf and Fomprey 1968). 

RDX and its partial reduction product hexahydro-l-nitroso-3,5-dinitro-l,3,5-triazine were degraded by K. pneumoniae to methylenedinitramine, and then to CHjO and methanol, while abiotic reactions produced NjO (Zhao et al. 2002). 

Ventilator 5. pneumoniae, MSSA, E. coli, K. pneumoniae, M. pneumoniae,... 

Health care MRSA, extended-spectrum P-lactamase-producing K. pneumoniae, P. aeruginosa, Acinetobacter spp. 

K+—potassium, univalent form —elimination rate constant K mob i I is—Klebsiella mob ills K. pneumoniae—Klebsiella pneumoniae KC104—potassium perchlorate kg—kilogram KI—potassium iodide... 

Alcoholism Aspiration pneumonia Pneumococcus, K pneumoniae, S. aureus, H influenzae, possibly mouth anaerobes Ticarcillin-clavulanate, piperacillin-tazobactam, plus aminoglycoside carba-penem,e fluoroquinolone ... 

Nosocomial pneumonia Gram-negative bacilli (such as K pneumoniae, Enterobacter spp.. Pseudomonas aeruginosa), 5. aureus Pi peraci 11 i n-tazo bacta rr carbapenem,e or extended-speclrum cephalosporin plus aminoglycoside, fluoroquinolone ... 

Prostatitis E coli K pneumoniae Proteus spp. P aeruginosa 1. Trimethoprim-sulfamethoxazole x 4-6 weeks 2. Quinolone x 4-6 weeks Acute prostatitis may require IV therapy initially Chronic prostatitis may require longer treatment periods or surgery... 

These infections are predominantly caused by E. coli, and antimicrobial therapy should be directed against this organism initially. Other causes include S. saprophyticus and occasionally K. pneumoniae and Proteus mirabilis. 

E. coli Vogel K. pneumoniae 39645 P. aeruginosa MGH-2 S. aureus Smith ... 

S. aureus A TCC 65S8P S. pyogenes 910 E. coli Juki K. pneumoniae 8045 P. aeruginosa 5007... 

S. aureus E. coli P. aeruginosa P. morganii K. pneumoniae E. clocacae... 

S. aureus B. subtilis E. coli K. pneumoniae S. paratyphi P. aeruginosa... 

Compound R R2 E. coli DNA gyrase E. coli H560 K. pneumoniae MGH-2 P. aeruginosa S. aureus UI-18 H-228 S. faecalis S. pneumoniae MGH-2 SV-1 S.pyogenes C203... 

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