K homology domain

An additional approach to the distinction of Merkel cell tumors from small cell pulmonary carcinomas involves the use of antibodies to the mammalian achaete-scute complex-like protein (MASH). Although more than 80% of small cell pulmonary carcinomas are MASH positive, only 1 of 30 Merkel cell carcinomas was positive for this marker. Merkel cell carcinomas also express the K homology domain containing protein (KOC), similar to other high-grade NE malignancies. 

Pryor JG, Simon R, Bourne PA, et al. Merkel cell carcinoma expresses K homology domain-containing protein over expressed in cancer similar to other high grade neuroendocrine carcinomas. Hum Pathol. 2009 40 238-243. 

Xu and associates used immunohistochemical analysis to study novel protein K homology domain containing protein overexpressed in cancer (KOC) in neuroendocrine lung cancers. KOC was stated to be a member of the insulin-like growth factor (IGF)... 

Xu H, Bourne PA, Spaulding BO, et al. High-gtade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer but carcinoid tumots do not. Hum Pathol. 2007 38 555-563. 

Ferguson, K.M., et al. Structure of the high affinity complex of inositol triphosphate with a phospholipase C pleckstrin homology domain. Celt 83 1037-1046, 1995. 

Touhara, K. Effects of mutations in pleckstrin homology domain on adrenergic receptor kinase activity in intact cells. Biochem. Biophys. Res. Commun., 252, 669-674 (1998)... 

Touhara, K. Binding of multiple ligands to pleckstrin homology domain regulates membrane translocation and enzyme activity of -adrenergic receptor kinase. FEBS Lett., 417, 243-248 (1997)... 

While glutamate residues in peptides of appropriate sequence are carboxylated by the vitamin K-depen-dent system, aspartate peptides scarcely react.503 Beta-carboxyaspartate is present in protein C of the blood anticoagulant system (Fig. 12-17)521 and in various other proteins containing EGF homology domains (Table 7-3),522 but the mechanism of its formation is unknown. 

Banuelos, S., Saraste, M., and Carugo, K. D. (1998). Structural comparisons of calponin homology domains Implications for actin binding. Structure 6, 1419-1431. 

Vectors for expressing proteins as fusions to a BCCP domain derived from Klebsiella pneumoniae are now available from Invitrogen (pET104 DEST Bioease). This K. pneumoniae domain is highly homologous to the E. coli BCCP protein and confers the same properties. 

K Turgay, M Krause, MA Marahiel. Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes. Mol Microbiol 6 529-546, 1992. 

Witte S, Villalba M, Bi K, Liu Y, Isakov N, Altman A. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. J Biol Chem 2000 275 1902-1909. 

Figure 7.5 Diagrammatic representation of the structure of a-subunit of vertebrate sodium channel showing the four internally homologous domains (I-IV), each containing six hydrophobic transmembrane helices. (From Soderlund, D.M., in Comprehensive Molecular Insect Science, Gilbert, L.I., Iatrou, K., and Gill, S.S., Eds., Vol. 5, Elsevier, London, 2005,1. With permission.)...

Mikami, K., Takahashi, S., Katagiri, T., Yamaguchi-Shinozaki, K., and Shinozaki, K., 1999, Isolation of an Arabidopsis thaliana cDNA encoding a pleckstrin homology domain protein, a putative homologue of human pleckstrin. J. Exp. Bot. 334 729-730. 

D. Timm, K. Salim, I Gout, 1— Guruprasad, M. Waterfield, and T. Blundell. Crystal structure of the pleckstrin homology domain from dynamin. Nature Struct Biol, 1 (11), 782 788, 1994. 

Cell Biol. 28, 1185-1189, 1996 Szymanski, P.T., Calponin (CaP) as a latch-bridge protein — a new concept in regulation of contractility in smooth muscle, J. Muscle Res. Cell Motil. 25,7-19,2004 Lehman, W., Craig, R., Kendrick-Jones, J., and Sulherland-Smith, A.J., An open or closed case for the conformation of calponin homology domains on F-actin J. Muscle Res. Cell Motil. 25, 351-358, 2004 Feijani, L, Fattoum, A., Maciver, S.K. et al., A direct interaction with calponin inhibits the actin-nucleating activity of gelsohn, Biochem. J. 396, 461 68, 2006. 

Luo HR, Huang YE, Chen JC, Saiardi A, lijima M, Ye K, Huang Y, Nagata E, Devreotes P, Snyder SH. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell 2003 114 559-572. 

TOUHARA K, INGLESE j. Pitcher JA, Shaw G, LEFKOWTTZ RJ. Binding of G protdn Py-subunits to pleckstrin homology domains. JBiol Chem 269 10217-10220,1994. 

Leminon, M. A., Falasca, M., Ferguson, K. M., and SchlessLnger, ]. (1997). Regulatory le-eniitment of signalLng molecules to the cell membrane by pleckstrln-homology domains. Trends Cell. Bioi. 7,237-242. 

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