Janeway

Janeway CA Jr, Travers P, Walport M et al (2005) Immunobiology the immune system in health and disease, 6th edn. Garland Science, New York... 

Janeway CA Jr Approaching the asymptote Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989 54 1-13. 

Janeway CA Jr, Medzhitov R Innate immune recognition. Armu Rev Immunol 2002 20 197-216. Kapsenberg ML Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 2003 3 984-993. 

Janeway, C.A. and Golstein, P. (1993). Lymphocyte activation and effector functions. The role of cell surface molecules. Curr. Opin. Immunol. 5, 313-323. 

Janeway lesions are small, painless hemorrhagic macular plaques on the palms of the hands or soles of the feet due to septic emboli and more commonly associated with acute S. aureus IE (Fig. 71-3F). 

Skin manifestations (e.g., petechiae, splinter hemorrhages, Osier nodes, Janeway lesions)... 

Vascular phenomena, major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway s lesions... 

Janeway, C. A., Jr., and Travers, P. (1994). Immunobiology The immune system in health and disease. (New York Garland Publishing). 

Medzhitov, R. and Janeway, C.A. (1997) Innate immunity the virtues of a nonclonal system of recognition. Cell 91,295-298. 

In an immune response, antibodies are produced and secreted by the B-lymphocytes in conjunction with the T, cells. In the majority of hapten-carrier systems, the B cells end up producing antibodies that are specific for both the hapten and the carrier. In these cases, the T lymphocytes will have specific-binding domains on the carrier, but will not recognize the hapten alone. In a kind of synergism, the B- and T-cells cooperate to induce a hapten-specific antibody response. After such an immune response has taken place, if the host is subsequently challenged with only the hapten, usually it will respond by producing hapten-specific antibodies from memory cells formed after the initial immunization. For a review of immunobiology (see Janeway, 2004). 

Osier s nodes / Janeway lesions / Splinter hemorrhages / Petechiae... 

Fever is common as well as a heart murmur (sometimes new or changing). The patient may or may not have embolic phenomenon, splenomegaly, or skin manifestations (e.g, Osier s nodes, Janeway lesions). Laboratory tests... 

Janeway, C., Travers, P., Walport, M. and Schlomchik, M.J., Immunobiology the Immune System in Health and Disease, 6th ed., Garland Publishing, New York, 2004. 

Medzhitov, R.., Prestonhurlburt, P. and Janeway, C. A., A human homologue of the Drosophila Toll protein signals activation of adaptive immunity, Nature, 388, 394, 1997. 

Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA Jr, Weiner HL Oral tolerance in myelin basic protein T-cell receptor transgenic mice suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci USA 1996 93 388-391. 

Janeway CA, Travers P, editors. Immunobiology. 5th ed. New York Garland, 2001. 

Janeway, C. A., P. Travers, Mark Walport, and M. Shlomchik. Immunobiology. New York, NY Garland Press, 2004. 

Janeway C et al Immunobiology The Immune System in Health and Disease, 7th ed. Current Biology Publications, 2008. Levinson WE, Jawetz E Medical Microbiology and Immunology. 7th ed. McGraw-Hill, 2008. 

A full understanding of self-discrimination is not yet available.2533 The adaptive system, as generally understood, is outlined in the following pages. A current view of the innate system is presented by Medzhitov and Janeway.113 However, an alternative... 

---