Activator of G protein signaling

Blumer, J. B. and Lanier, S. M. Accessory proteins for G protein-signaling systems activators of G protein signaling and other nonreceptor proteins influencing the activation state of G proteins. Receptors Channels 9 195-204, 2003. 

Sato, M., Cismowski, M. J., Toyota, E., et al. (2006) Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma. Proc. Natl. Acad. Sci. U. S. A. 103, 797-802. 

Fig. 2 Yeast-based functional screen for receptor-independent activators of G-protein signaling. The yeast strain indicated in A was generated as described previously (Cismowski et al. 1999, 2002) and transformed with mammalian cDNA libraries in the galactose-inducible yeast expression vector pYES2. The strategy for identifying mammalian cDNAs that promoted growth (i.e., activated G-protein signaling pathway) is indicated in B. GALlp GALl promoter)...

Adhikari A, Sprang SR (2003) Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha il. J Biol Chem 278 51825—51832... 

Bowers MS, McFarland K, Lake RW, Peterson YK, Lapish CC, Gregory ML, Lanier SM, KaUvas PW (2004) Activator of G protein signaling 3 a gatekeeper of cocaine sensitization and drug seeking. Neuron 42 269-281... 

DeVries L, Fischer T, Tronchere H, Brothers GM, Strockbine B, Siderovski DP, Farquhar MG (2000) Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha 1 subunits. Proc Natl Acad Sci USA 97 14364-14369... 

GRK), Regulator ofG protein signaling (RGS), Activator of G protein signaling (AGS), Hypertension,... 

Blumer JB, Smrcka AV, Lanier SM (2007) Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling. Pharmacol Ther 113 488-506... 

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