Levodopa Isoniazid

Azithromycin, fluoroquinolones, ketoconazole, isoniazid, penicillin, rifampin, and tetracycline ° Didanosine, indinavir, stavudine, and zidovudine ° Aledronate, risedronate, and levodopa... 

Pyridoxine [Vitamin B ] [Vitamin B Supplement] U e Rx prevention of vit B6 deficiency Action Vit supl Dose Adults. Deficiency 10-20 mg/d PO Drug-induced neuritis 100-200 mg/d 25-100 mg/d prophylaxis Peds. 5-25 mg/d x 3 wk Caution [A (C if doses exceed RDA), +] Contra Component aUCTgy Disp Tabs 25, 50, 100 mg inj 100 mg/mL SE Allergic Rxns, HA, N Interactions -1- Effects OF levodopa, phenobarbital, phenytoin EMS Can be used as an antidote for isoniazid poisoning OD May cause sensory nerve damage (numbness, tingling, reduced sensation) and coordination problems Sxs are usually revised aft stopping pyridoxine symptomatic and supportive... 

Drugs that are considered to be absorbed to a lesser degree with food include antibiotics (ampicillin, penicillins G and VK, isoniazid, rifampicin, lincomycin, nafcillin, tetracyclines), methyldopa and levodopa (to be... 

Adrenaline, apomorphine, ascorbic acid, benserazide, dihydralazine, dobutamine, dodecyl gallate, dopamine, ethylnoradren-aline, hexoprenaline, hydralazine, iproniazid, isocarboxazid, isoetharine, isoniazid, isoprenaline, levodopa, meban-azine, methyldopa, methyldopate, nialamide, noradrenaline, phenelzine, procarbazine, protokylol, rimiterol... 

Vitamin B complex is the collective term for a number of water-soluble vitamins found particularly in dairy products, cereals and liver.Vitamin B (thiamine) is used by mouth for dietary supplement purposes and by injection in emergency treatment of Wernicke-Korsakoff syndrome. Vitamin B2 (riboflavin) is a constituent of the coenzyme FAD (flavine adenine dinucleotide) and FMN (flavine mononucleotide) and is therefore important in cellular respiration. Vitamin Be (pyridoxine) is a coenzyme for decarboxylases and transamination, and is concerned with many metabolic processes. Overdose causes peripheral neuropathy. It may be used medically for vomiting and radiation sickness and for premenstrual tension. Pyridoxine has a negative interaction with the therapeutic use of levodopa in parkinsonism by enhancing levodopa decarboxylation to dopamine in the periphery, which does not then reach the brain. The antitubercular drug isoniazid interferes with pyridoxine, and causes a deficiency leading to peripheral neuritis that may need to be corrected with dietary supplements. Vitamin B ... 

Antidepressants selective serotonin reuptake inhibitors, tricyclic antidepressants Antihypertensives felodipine Antibiotics quinolones, isoniazid Bronchodilators albuterol, theophylline Corticosteroids prednisone Dopa agonists levodopa Herbals ma huang, ginseng, ephedra Nonsteroidal anti-inflammatory drugs ibuprofen Stimulants amphetamines, methylphenidate, caffeine, cocaine Sympathomimetics pseudoephedrine Thyroid hormones levothyroxine Toxicity anticholinergics, antihistamines, digoxin Withdrawal alcohol, sedatives... 

Following the observation that levodopa-induced dyskinesias were reduced by isoniazid in one patient, a further study was undertaken in 20 others taking levodopa plus a dopa-decarboxylase inhibitor. It was found that isoniazid (average dose 290 mg daily, range 100 to 800 mg daily) reduced the dyskinesias of 18 of the 20 patients. However, the reduction in dyskinesias was accompanied by an intolerable worsening of parkinsonism, shown by decreased mobility and greater ofP periods. The reduction... 

An isolated report describes a patient on levodopa who developed hypertension, agitation, tachycardia, flushing and severe non-parkinsonian tremor after starting to take isoniazid. He recovered when the isoniazid was stopped. ... 

Not understood. Metabolic studies in one patient suggest that isoniazid inhibits dopa-decarboxylase, although other mechanisms have been proposed. The isolated case of hypertension and tachycardia is also not understood, but it has been suggested that it may have been due to a weak monoamine oxidase inhibitory effect of the isoniazid metabolites. See MAOIs or RIMAs + Levodopa , p.l 136, for finther explanation. 

Spectrophotometric methods for the determination of catecholamine derivatives pyrocatechol, dopamine, levodopa, and methyldopa have been developed and applied to injections and tablets. One of the methods involves the oxidation of o-dihydroxy benzene derivatives by N-bromosuccinimide followed by oxidative coupling with isoniazide, leading to the formation of a red-colored product of maximum absorbance at 480-490 nm. 

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