Benign intracranial

Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea, and vomiting, and visual disturbances. Screen patients with these symptoms for papilledema and, if present, advise the patients to discontinue danazol immediately and refer them to a neurologist for further diagnosis and care. 

Intracranial hypertension Danazol has been associated with several cases of benign intracranial hypertension (also known as pseudotumor cerebri) (see Black Box Warning). 

Pseudotumor cerebri Pseudotumor cerebri (benign intracranial hypertension) in adults has been associated with tetracycline use. 

Cardiovascular - Benign intracranial hypertension (pseudotumor cerebri) has been reported rarely. Bulging fontanels, as a sign of benign intracranial hypertension in infants, have been reported rarely. Changes in electrocardiogram (eg, nonspecific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions. 

Benign intracranial hypertension (pseudotumor cerebri) occurs rarely. 

Superinfection (especially fungal), anaphylaxis, and benign intracranial hypertension occur rarely. 

Monitor the patient s LOG because of the potential for benign intracranial hypertension... 

Long-term glucocorticoid treatment can result in papilledema and increased intracranial pressure (the syndrome of pseudotumor cerebri or so-called benign intracranial hypertension ), particularly in children. 

Benign intracranial hypertension occurred in a 7-month-old child after withdrawal of topical betamethasone ointment and in a 7-year-old boy treated with a 1% cortisol ointment in large amounts. 

A 6-year-old girl, who had taken prednisone for 2.5 years for nephrotic syndrome with seven relapses in 3 years, developed symptoms of benign intracranial hypertension after oral glucocorticoid dosage reduction over 10 months from 30 mg/day to 2.5 mg/every other day (46). Laboratory studies and head CT scan were normal, but there was bilateral papilledema and the cerebrospinal fluid pressure was increased. She was given prednisone 1 mg/kg/day initially, with acetazola-mide, and 25 ml of cerebrospinal fluid was removed. All her symptoms resolved and treatment was gradually withdrawn. She developed no further visual failure. 

Benign intracranial hypertension with nasal glucocorticoids has been reported (439). 

Lorrot M, Bader-Meunier B, Sebire G, Dommergues JP. Hypertension intracranienne benigne une complication meconnue de la corticotherapie. [Benign intracranial hypertension an unrecognized complication of corticosteroid therapy.] Arch Pediatr 1999 6(l) 40-2. 

Bond DW, Charlton CP, Gregson RM. Benign intracranial hypertension secondary to nasal fluticasone propionate. BMJ 2001 322(7291) 897. 

A 32-year-old woman who was not obese developed benign intracranial hypertension in association with ovarian hyperstimulation syndrome after ovulation induction using goserelin, follitropin, and human chorionic gonadotropin (hCG) (3). The syndrome did not recur during a second pregnancy in which follitropin and hCG were not used... 

Lesny P, Maguiness SD, Hay DM, Robinson J, Clarke CE, Killick SR. Ovarian hyperstimulation syndrome and benign intracranial hypertension in pregnancy after in-vitro fertilization and embryo transfer case report. Hum Reprod 1999 14(8) 1953-5. 

A 32-year-old woman who was not obese developed benign intracranial hypertension in association with... 

Malozowski S, Tanner LA, Wysowski DK, Fleming GA, Stadel BV. Benign intracranial hypertension in children with growth hormone deficiency treated with growth hormone. J Pediatr 1995 126(6) 996-9. 

Crock PA, McKenzie JD, Nicoll AM, Howard NJ, Cutfield W, Shield LK, Byrne G. Benign intracranial hypertension and recombinant growth hormone therapy in Australia and New Zealand. Acta Paediatr 1998 87(4) 381-6. 

Bala P, McKiernan J, Gardiner C, O Connor G, Murray A. Turner s syndrome and benign intracranial hypertension with or without growth hormone treatment. J Ped Endocrinol Metab 2004 17 1243 1. 

Higgins JN, Owler BK, Cousins C, Pickard JD (2002) Venous sinus stenting for refractory benign intracranial hypertension. Lancet 359 228-230... 

Pseudotumor cerebri Benign intracranial hypertension characterized by headache and blurred vision may occur in adults. Though discontinuation of the drug reverses the condition, it is not clear whether permanent sequelae may occur. 

Pseudotumor cerebri (benign intracranial hypertension) has been linked to lithium in over 30 cases, with headache, papilledema, increased intracranial pressure, reduced vision, and a risk of blindness (201). The condition tends to improve on withdrawal, but surgical intervention may sometimes be necessary. A review of pseudotumor cerebri devoted one paragraph to induction of this condition by lithium and provided six references but no new information (202). 

Tehindrazanarivelo A, Evrard S, Schaison M et al (1992). Prospective study of cerebral sinus venous thrombosis in patients presenting with benign intracranial hypertension. 

RETINOIDS ANTIBIOTICS Risk of benign intracranial hypertension with tetracycline Unknown Avoid co-administration... 

Tetracyclines induce photosensitisation and other rashes. Liver and pancreatic damage can occur, especially in pregnancy and with renal disease, when the drugs have been given i.v. Rarely tetracyclines cause benign intracranial hypertension, dizziness and other neurological reactions. 

A 35-year-old woman with benign intracranial hypertension and high blood pressure was given amlodipine, with good control of her blood pressure (8). However, her headache worsened and she developed papilledema. The CSF pressure was 30 cm. Her symptoms disappeared shortly after amlodipine withdrawal. 

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