International sensitivity index

The international normalized ratio (INR) is a method to standardize repotting of the prothrombin time, using the formula, INR = (PTpatie t/PTcontroi)ISI, where PT indicates the prothrombin times (for the patient and the laboratory control), and ISI indicates the international sensitivity index, a value that varies, depending upon the thromboplastin reagent and laboratory instrument used to initiate and detect clot formation, respectively. 

ACCP American College of Chest Physicians ISI International Sensitivity Index... 

International Normalized Ratio (INR) The ratio of the patient s clotting time to the clinical laboratory s mean reference value normalized by raising it to the International Sensitivity Index (ISI) power to account for differences in thromboplastin reagents. Therefore, INR = (patient s prothrombin time/laboratory s mean normal prothrombin time)ISI. 

The relationship between INR on cotherapy and warfarin alone is dependent on the dose of argatroban and the thromboplastin reagent used. Thromboplastins with higher International Sensitivity Index (ISI) values result in higher INRs on combined therapy of warfarin and argatroban. 

Ts ao C, Swedlund J, Neofotistos D. Implications of use of low international sensitivity index thromboplastins in prothrombin time testing. Arch Pathol Lab Med 1994 118 1183-7. 

The International Sensitivity Index (ISI) is a measure of the thromboplastin s responsiveness compared with the WHO reference standard. Each thromboplastin reagent manufactured has an ISI valne that should be used to calculate the INR. Although the INR system has a number of potential problems, it is currently the best means available... 

International normalised ratio (INR). The DSTR was adopted by the WHO in 1982 to standardise (using the International Sensitivity Index) oral anticoagulant therapy to take into account the sensitivities of the different thromboplastins used in laboratories across the world. The formula for calculating the INR is as follows ... 

Diffuse large B-cell lymphomas are the most common lymphoma in patients of all ages but most commonly seen in the seventh decade. Extranodal disease is present at diagnosis in 30% to 40% of patients. The International Prognostic Index score correlates with prognosis. Diffuse aggressive lymphomas are sensitive to chemotherapy with cure achieved in some patients. 

Childhood Anxiety Sensitivity Index (CASI) Private, via author W.K. Silverman, Ph.D., Department of Psychology, Florida International University, University Park, Miami, EL also in Werry, J.S. and Aman, M.G. eds.. Practitioner s Guide to Psychoactive Drugs for Children and Adolescents. New York Plenum. 

In conclusion, important progresses are taking place in the standardisation of the survey methods used in IDD evaluation. At the same time new developments such as the introduction of thyroid echography improves the reliability of goitre prevalences assessment but international norms and directives will be needed for the presentation of these new data. With borderline low iodine intake, the percentage of recalled newborns obtained in neonatal screening for neonatal hypothyroidism is a sensitive index of the severity of the iodine deficiency. In former East of Europe where the... 

Some of the internal salts derived from /V-hcterocycles are dangerously explosive solids, sensitive to modest heating and to impact, also liable to violent spontaneous decomposition, even in solution. A related A-nitroimide (hetero-N—NH—NO2) was also explosive. It is possible the benzotriazolium imidates were also, in fact, the tautomeric nitroaminobenzotriazoles. None of their potassium salts exploded [1]. Related chemistry has been examined with a view to new explosives, in particular l,4-bis(nitroamino)-l,4-diazabicyclo[2.2.2]octane, said to be surprisingly stable.The individually indexed unstable compounds are ... 

The interferometric sensor platform is highly sensitive and is the only one that provides an internal reference for compensation of refractive-index fluctuations and unspecific adsorption. Interferometric sensors have a broader dynamic range than most other types of sensors and show higher sensitivity as compared to other integrated optical biosensors . Due to the high sensitivity of the interferometer sensor the direct detection of small... 

The most useful of the known photorefractives are LiNbC>3 and BaTiC>3. Both are ferroelectric materials. Light absorption, presumably by impurities, creates electron/hole pairs within the material which migrate anisotropically in the internal field of the polar crystal, to be trapped eventually with the creation of new, internal space charge fields which alter the local index of refraction of the material via the Pockels effect. If this mechanism is correct (and it appears established for the materials known to date), then only polar, photoconductive materials will be effective photorefractives. However, if more effective materials are to be discovered, a new mechanism will probably have to be discovered in order to increase the speed, now limited by the mobility of carriers in the materials, and sensitivity of the process. 

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