Interest model

These results indicate that is it possible to change the fold of a protein by changing a restricted set of residues. They also confirm the validity of the rules for stability of helical folds that have been obtained by analysis of experimentally determined protein structures. One obvious impliction of this work is that it might be possible, by just changing a few residues in Janus, to design a mutant that flip-flops between a helical and p sheet structures. Such a polypeptide would be a very interesting model system for prions and other amyloid proteins. 

The neural mechanisms underlying the placebo effect are only partially understood and most of our knowledge comes from pain, although recently Parkinson s disease, immune and endocrine responses, and depression have emerged as interesting models (Fig. 1). In each of these... 

In addition, it sustains CO electro-oxidation at relatively low overpotential, and there are crystal face dependences for both the ORR and CO oxidation. Since Au is also a system that exhibits both particle size and support effects in heterogeneous catalysis, it provides an interesting model system for smdying such effects in electrocatalysis. 

The protein-containing colloidal solutions of water-in-organic solvents are optically transparent. Hence, absorption spectroscopy, circular dichroism spectroscopy and fluorescence spectroscopy are found to be convenient for studying biocatalysis [53]. The reversed micelles are interesting models for studying bioconversion, since the majority of the enzymes in vivo act inside or on the surface of biological membranes. 

The vanadium complex 159, bearing oligometallasilsesquioxanes, is an interesting model complex for surface species on silica [257]. Polymerization of ethylene with 159/MAO affords polyethylene with an Mn value of 2100 and an Mw value of 47900. An aluminum-vanadium adduct 160 polymerized ethylene without any cocatalysts, affording similar catalytic activity with the 159/MAO system [258]. 

In the present section we will present the shape characterization of different types of gold particles which are present on an evaporated film grown on a NaCl substrate. This is an interest model not only for epitaxy studies but also because the same shapes are found in real catalyst. 

As for the modeling of in vitro and in vivo potencies and selectivities, some interesting models were obtained on a subset of representative ligands. In fact, the QSAR analysis of functional activities for this set of compounds, although numerically limited, yields successful correlations [97]. Among these linear correlations, the following equation constitutes a significant example ... 

These examples have demonstrated that it is possible to use the templating properties of a compound to accelerate its own formation. This is a potentially very attractive approach for the production of large quantities of a specific product with high selectivity. Furthermore, synthetic self-replicating systems also provide interesting models for their biological counterparts, which in turn could provide important clues to understand chemical evolution and indeed the origin of life itself. 

Since an exhaustive search—eventually combined with exhaustive evaluation— is practically impossible, any variable selection procedure will mostly yield subopti-mal variable subsets, with the hope that they approximate the global optimum in the best possible way. A strategy could be to apply different algorithms for variable selection and save the best candidate solutions (typically 5-20 variable subsets). With this low number of potentially interesting models, it is possible to perform a detailed evaluation (like repeated double CV) in order to find one or several variables... 

From these considerations the osteopetrosis has emerged as extremely interesting model disease. Below, naturally occurring (Table 1) and produced by gene targeting (Table 2) diseases with the common denominator of osteopetrosis would be reviewed in view of their contribution to the understanding the physiology of bone resorption. 

In addition to erosion, an interesting model for dishing within metal features is proposed, based on the concept of a maximum dishing, which... 

Autism is an interesting model for the study of consciousness. The combination of social isolation, language impairment and restricted, repetitive interests and behaviours together with idiosyncratic patterns in attention, concentration and interpersonal behaviour offer opportunities for the exploration of certain aspects of consciousness ... 

Takahashi You have an interesting model for testing Pittendrigh s internal versus external coincidence idea. You can ask whether light is necessary by using T cycles driven by temperature. This is what Pittendrigh always wanted to do. You just have to drive for 21 or 28 h with temperature, change the phase and if it is internal coincidence you will get photoperiodic induction, if it is external you won t. 

Fig. 7 Results from behavioral testing in the modified hole board (see Sect. 2.2.5). While DBA/2 mice (DBA) display a more pronounced avoidance behavior towards an unprotected area as well as more risk assessment behavior than C57BL/6 (BL6) mice, no differences in term of general exploration and locomotion are found in these strains. Therefore, these strains can be considered to represent an interesting model for high and low anxiety...

Some components of the splicing apparatus appear to be tethered to the CTD of RNA polymerase II, suggesting an interesting model for the splicing reaction. As the first splice junction is synthesized, it is bound by... 

Our approach has been essentially empirical in nature with less emphasis on the theoretical. We have isolated single substances, proved their purity, and determined their covalent structure by classical methods of organic chemistry we have then used these substances of molecular weight ranging from 1,000 to 14,000 as model solutes for the study of conformation and intermolecular interaction. Solutes of special interest have been gramicidin SA (2), bacitracin A (3), polymyxin B, and the tyrocidines A, B, and C (4). All are cyclic antibiotic polypeptides. The first three behave in aqueous solution as reasonably ideal solutes and do not associate, but the tyrocidines associate strongly and are interesting models for the study of association phenomena. Other model solutes of... 

The effect of strain amplitude is most pronounced in compounds containing reinforcing fillers and can result in a reduction in shear modulus of as much as a factor of 4 when going from a very small strain to about 10%. This is due to breakdown of filler structure which is associated with energy losses that cause a peak in the tan8 value. It was because of this that earlier British and international standards called for tests to be made at 2 and 10% shear strain, a sensible recommendation that has been overlooked in the present version. Turner6 produces an interesting model based on frictional elements to explain this behaviour. 

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