EGF-like repeats

The Drosophila Notch 1 is a 300-kDa integral membrane protein that contains 36 EGF-like repeats. 

Notch. The notch gene in Drosophila encodes a receptor-like transmembrane protein with EGF-like repeats. Notch is essential for ectoderm differentiation. 

Both Notch and its ligand Delta are transmembrane proteins with numerous EGF-like repeats in their extracellular domains. They participate in a highly conserved and important type of cell differentiation in both Invertebrates and vertebrates, called lateral inhibition, in which adjacent and devel-opmentally equivalent cells assume completely different fates. This process, discussed in detail In Chapter 15, is particularly important in preventing too many nerve precursor cells forming from an undifferentiated layer of epithelial cells. 

V contains EGF-like repeats. Structural variation can exist within the core protein due to alternative spicing in domain IV (115). GAG-attachment sites have been described in both the N-terminal domain I (116) and the C-terminal domain... 

The third domain (residues 80 to 244) of protein S is homologous to the EGF-like domains found in factors IX, X, VII, protein C and protein Z (see section FACTORS VII, IX, X AND PROTEIN C). However, protein S has four EGF-like repeats. The disulfide bond pairing has not been characterized in this region of any vitamin K-dependent protein. However, there is probably independent folding of the four structural units, leading to a disulfide bond arrangement identical to that in EGF (116). Based on this assumption, the half cystine residues from positions 80 to 245 were paired in disulfide bonds (96). Asp-95 in the amino terminal EGF domain is hydroxylated to erythro-beta-hydroxyaspar-... 

TIE-2 /angiopoietin-1 Extracellular domain containing two immunoglobulin-like loops separated by three EGF-like repeats cormected to three fibronectin type III-like repeats The ligand for TIE-2 is angiopoietin-1 Endothelial cells in mice, rats, and humans Rabbit anti- angiopoietin-1. Abeam, Cambridge, MA... 

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