Integrity targets

Darvas, F, Dorman, G., Puskas, L. G., Buesai, A., and Urge, L. 2004. Chemical genomics for fast and integrated target identification and lead optimization. Med. Chem. Res. 13 643-59. 

The FHA is a systematic, comprehensive examination of a system s fnnctions to identify potential failure conditions which the system can either cause or contribute to. It should therefore be performed early in the design and updated as required until all functional integrity targets are accomplished. 

The integrity target value is the expected munber of DU-failures that would occur if the rate of DU-failures were as assumed in the previous phase (here, in the design phase), i.e.. 

Step 2 Comparing integrity performance with integrity target values... 

This chapter is concerned with the utilization of the bacteriophage PI derived site-specific recombinase protein Cre (3-5), and its employment as a means to catalyze modifications in homologously recombined and randomly integrated target sites within the mouse genome. 

The specification of Human Integrity Targets through a HEA of physical system interactions directed by initial system hazard analyses. 

The specification and realisation of Human Integrity Targets relating to the success-case human tasks. 

Human subsystems must be specified and acceptable Human Integrity Targets specified for the identified sources of human error. In addition, the validation and verification of the achievement of the allocated Human Integrity Targets for each human subsystems is also required (this may include procedures as well as people). 

There has been extensive operating experience of the components used as part of the E/E/PE safety-related system in a similar environment and, as a minimum, used in a system of comparable complexity level AND there is sufficient hardware failure data, etc. to allow sufficient confidence in the hardware safety integrity target failure measure that is to be claimed. 

In an earlier paragraph we introduced the idea of needing to address safety-integrity targets both quantitatively and qualitatively ... 

The reason for there being effectively two tables (high and low demand) is that there are two ways in which the integrity target may need to be described. The difference can best be understood by way of examples. 

The Meaning and Context of Safety Integrity Targets 21 Table 1.2 H AZOF team typical roles and responsibilities. 

Assessing quantified integrity targets is an essential part of the design process (including retrospective safety studies). This leads to ... 

In order to set a quantified safety integrity target, a target Maximum Tolerable Risk is needed. It is therefore useful to be aware of the following rates ... 

Safety-Related System Maintenance This involves maintaming a system and controlling modifications so as to maintain the safety-integrity targets. 

This would imply a safety integrity target of SIL 2 (high demand). 

Random Hardware Failures ALARP Integrity Targeting Life-Cycle Activities Architectures (SFF)... 

This standard provides detail of those activities related to setting and achieving specific safety-integrity targets and involves the design, installation, maintenance, and modification stages of the life cycle. Where the activity in question is already catered for elsewhere in the XYZ Ltd quality management system, this document will provide the appropriate cross-reference. 

There are two circumstances in which an integrity target will arise ... 

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