Insulin long-acting

Human Extended Insulin Zinc Suspension. Ultralente Humulin U is a long-acting form of human insulin produced by recombinant DNA techniques. It is adrninistered subcutaneously and should not be given intravenously. The time course of this preparation is similar for onset of activity but shorter for maximum activity and duration of action compared with ultralente preparations of animal origin. Insulins of the lente series can be mixed in any proportion to obtain the desired dose and modified activity. 

Insulin glargine is given SC once daily at bedtime This type of insulin is used in the treatment of adults and children with type 1 diabetes mellitus and in adults widi type 2 diabetes who need long-acting insulin for die control of hyperglycemia. 

Long-Acting Insulin Glargine Lantus Aventis U-100 4-5 hours Flat 22-24 1 0 mL vial, 3 mL cartridge for Opticlik... 

Administer intermediate or long-acting insulin as soon as patient is eating. Allow for overlap in insulin infusion and subcutaneous insulin injection. 

GH, growth hormone Gl, gastrointestinal IGF-I, insulin-like growth factor I IM, intramuscularly LAR, long-acting release MRI, magnetic resonance imaging SQ, subcutaneously. 

Shechter, Y., Mironchik, M., Rubinraut, S., Saul, A., Tsubery, H., and Fridkin, M. (2005) Albumin-insulin conjugate releasing insulin slowly under physiological conditions A new concept for long-acting insulin. Bioconjugate Chem. 16, 913-920. 

Long-acting insulins Amino acid substitutions generate a product that enters the bloodstream very slowly from the site of injection, thereby maintaining basal insulin blood levels over an extended period 11... 

Actrapid/Velosulin/ Monotard/ Insulatard/ Protaphane/ Mixtard/ Actraphane/ All contain recombinant human insulin produced in S. cerevisiae formulated as short/ intermediate/long acting product) Identical to native human insulin Novo Nordisk 2002 (EU)... 

Levemir (Insulin detemir) Recombinant long-acting human insulin analogue produced in S. cerevisiae Engineered devoid of B30 threonine and a C14 fatty acid is covalently attached to B29 lysine Novo Nordisk 2004 (EU)... 

Lantus (Insulin Recombinant long-acting Engineered A 21 asparagine Aventis 2000 (USA... 

Table 11.4 Some pharmacokinetic characteristics of short, intermediate and long-acting insulin preparations...

Long-acting insulins Lantus (insulin glargine) Yes Vial, 3-mL OptiClik pen system... 

Glargine and detemir are long-acting peakless human insulin analogs that result in less nocturnal hypoglycemia than NPH insulin when given at bedtime. 

Insulin, a hormone produced by the pancreas, is essential for the metabolism of glucose, proteins, and fats. Insulins are classified on the basis of the duration of action as rapid-, intermediate-, or long-acting and on the basis of source or species, such as human or animal (beef, pork, and mixtures of beef and pork). Table 10.1 summarizes insulin preparations currendy available in the United States. 

Mixtard, human 70% NPH 30% regular premix (Nordisk) Long-Acting Insulins Standard 100 Human, semisynthetic... 

Insulin aspart Because insulin aspart has a more rapid onset and a shorter duration of action than human regular insulin, insulin aspart normally should be used in regimens together with an intermediate or long-acting insulin. NovoLog may be infused subcutaneously by external insulin pumps. 

Insulin detemir Treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia. 

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