Human regular insulin

Insulin aspart Because insulin aspart has a more rapid onset and a shorter duration of action than human regular insulin, insulin aspart normally should be used in regimens together with an intermediate or long-acting insulin. NovoLog may be infused subcutaneously by external insulin pumps. 

INSULIN Human regular insulin is best given 30 to 60 minutes before a meal. Administer maintenance doses subcutaneously. 

Treatment of patients with diabetes mellitus for the control of hyperglycemia often used to produce a more rapid onset and shorter duration of action than human regular insulin GI 124617 insulin precursor PID gl24617 Lys(B28)Pro(B29)-human insulin PDB ID ILPH... 

Radermecker RP, Scheen AJ. Continuous subcutaneous insulin infusion with short-acting insulin analogues or human regular insulin efficacy, safety, quality of life, and cost-effectiveness. Diabetes Metab Res Rev 2004 20 178-88. 

Tupola S, Komulainen J, Jaaskelainen J, Sipila I. Post-pran-dial insulin lispro vs. human regular insulin in prepubertal children with Type 1 diabetes mellitus. Diabet Med 2001 18(8) 654-8. 

Hoyer, G.L. Nolan, P.E., Jr. LeDoux, J.H. Moore, L.A. Selective stability-indicating high-performance Uqmd chromatographic assay for recombinant human regular insulin. J.Chromatogr.A, 1995, 699, 383-388... 

Ross SA, Zinman B, Campos RV, Stack T. A comparative study of insulin lispro and human regular insulin in patients with type 2 diabetes mellitus and secondary failure of oral hypoglycemic agents. Clin Invest Med 2001 24(6) 292-298. 

A. Parenterai. Human regular insulin (Humulin R, Novulin R), 100 U/mL, 10-mL vials. Only human regular insulin can be administered intravenously. ... 

NPH Isophane Human Insulin Suspension. NPH isophane insulin, also called Humulin N, Insulatard NPH Human, or Novolin N is an intermediate-acting form of human insulin produced by recombinant DNA techniques. Mixtures Humulin 70/30 and Novolin 70/30 contain 70% NPH isophane and 30% regular, whereas Humulin 50/50 contains 50% NPH isophane and 50% regular. It is adrninistered subcutaneously and should not be given intravenously. Absorption is delayed because the insulin is conjugated with protamine in a complex of reduced isoelectric solubiUty. Therapeutically, this preparation is probably comparable to purified porcine NPH insulin. However, human NPH insulin may have a slightly shorter duration of action than comparable purified porcine products. 

METHODS OF ADMINISTERING INSULIN. Several methods can be used to administer insulin. The most common method is the use of a needle and syringe Use of microfine needles has reduced the discomfort associated with an injection. Another method is the jet injection system, which uses pressure to deliver a fine stream of insulin below the skin. Another method uses a disposable needle and special syringe The syringe uses a cartridge that is prefilled with a specific type of insulin (eg, regular human insulin, isophane [NPH] insulin, or a mixture of isophane and regular insulin). 

Regular insulin human injection (rDNA origin) [FDA for Humulin R]... 

Novolog injection (insulin Novo Nordisk aspart) [human regular (rDNA origin)(B28 asp regular human insulin analog)]... 

Mixture of 70% NPH, human SC insulin isophane suspension and 30% regular, human insulin injection cloudy or milky suspension of human insulin with protamine and zinc... 

Insulin, Human Isophane Suspension Insulin, Human NPH Insulin, Human Regular... 

Insulin, Human Regular and Human NPH Mixture Insulin, Human, Zinc Suspension Insulin, Lispro Solution Insulin, NPH... 

Human insulin from E coli is available for clinical use as Humulin (Lilly) and dispensed as either regular, NPH, lente, or ultralente Humulin. Human insulin prepared biosynthetically in yeast is marketed by Novo Nordisk as human insulin injection in regular, lente, and NPH forms Novolin R, Monotard Human Insulin (Novolin L), and Novolin N. The same company also produces a human insulin marketed as Velosulin (regular) that contains a phosphate buffer. This reduces aggregation of regular insulin molecules when used in infusion pumps. However, because of the tendency of phosphate to precipitate zinc ions, Velosulin should not be mixed with any of the lente insulins. 

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