Human insulin analogs

Glargine and detemir are long-acting peakless human insulin analogs that result in less nocturnal hypoglycemia than NPH insulin when given at bedtime. 

Lepore, M., S. Pampanelli, C. FanelU, F. Forcellati, L. Bartocci, A. Di Vincenzo, C. Cordoni, E. Costa, P. Brunetti, and G.B. Bolli, Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro. Diabetes, 2000. 49(12) 2142-8. 

LANTUS (insulin glargine) Sanofi-Aventis [.E. coft-expressed recombinant human insulin analog]... 

Units/mL human insulin analog suspension containing 70% insulin aspart protamine crystals and 30% soluble insulin... 

Category Human Insulin analog, long-acting Half-life 5-7 hours... 

Insulin lispro (rDNA origin) is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at positions 28 and 29 on the insulin B-chain are reversed. It has the empirical formula C257H383N65077S6 and a MW of 5808, both identical to that of human insulin. 

Figure 6. Disappearance curves of hexameric human insulin (O), the monomeric human insulin analog B9Asp, B27Glu( ), and the dimeric human insulin analog BlOAsp (V) in a logarithmic scale. Straight-line segments were calculated by linear regression analysis using the data fiom the relevant time intervals. (From Brange et ai, 1990, with permission.)...

Code in Fig. 5 Human insulin analog (substitutions) Negative charge added (pH 7)... 

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