Insecticidal agents

The effectiveness of some of the new insecticidal agents against an extremely wide variety of disease vectors has made possible the control of many important diseases which previously defied all practical efforts at control and has brought within the realm of possibility the ultimate eradication of certain diseases. 

The use of insecticidal agents on wool to prevent attack by moth and beetle larvae. 

Ins./Argentina/worldwide irodoids iridotnyimecin insecticidal agents... 

The identification of new natural product structural classes active against insects will attack the pest-resistance problem and provide environmentally safer insecticides. The marine environment, with its chemical diversity, clearly holds an enormous potential to provide leads for the development of insecticidal agents. Many marine-derived structural classes have not yet been examined for their insecticidal activity. Further SAR studies of these marine natural products could lead to new and more selective insecticidal agents. 

El Sayed KA, Dunbar DC, Perry TL, Wilkins SP, Hamann MT, Greenplate JT, Wideman MA (1997) Marine Natural Products as Prototype Insecticidal Agents. J Agric Food Chem 45 2735... 

H. Ikegami, K. Umeda, K. Tsushima, N. Matsuo, The discovery of pyridalyl a novel insecticidal agent for controlling lepidopterous pests, Pest Manage. Sci. 60 (1)... 

Phosphate esters used as insecticidal agents are toxic and must be handled with extreme caution. Symptoms of toxicity arenau.sea. vomiting, excessive sweating, salivation, miosis, bradycardia, low blood pressure, and respiratory difficulty, which is the usual cau.se of death. 

Certain neurotoxicants act by directly influencing the electrical activity of the insect nerve membrane through a specific action at ion-selective channels. These phenomena can be studied using many of the neurobiochemical techniques that have successfully been applied to vertebrate nervous systems. In this study we use the technique of insect synaptosomes in superfusion to examine the interaction of a range of insecticidal agents with ion channels in the nerve terminal by monitoring effects on transmitter release. 

It is generally recognized that the widespread use of insecticides has two serious side-effects evolution of insecticide resistance in insects and danger to environmental and human safety. The continued use of insecticides requires stricter agricultural practices as well as the improvement of the chemicals themselves. Equally as important, however, new strategies for development of insecticidal agents are needed (1-3). 

Dithianes substituted at the 2 and 5 positions, and their sulfoxides, are insecticidal agents. Optimum activity was observed for 5-/-butyl derivatives with either 2-phenyl or 2-cyano substituents <92Mi 608-02). The mode of action is thought to be similar to that of the insecticidal 2,6,7-trioxabicyclo[2.2.2]octanes. Investigations of the oxidation, metabolism, and photoactivity of these materials have been carried out <92Mi 608-03,92Mi 608-04,94JMC133). In related work, 2,5-disubstituted-... 

The dipeptide 250 is prepared from amino adenine 248 and Boc-D-Ala 249 using DEPC as the coupling agent. 1 The amino acid carrying the adenine in the side chain has been employed for the synthesis of the naturally occurring dipeptide NK3 74200, a novel insecticide agent isolated from the culture of the fungus Talaromyces sp,9]... 

From the above it is < wious that fatty acids and saponified products of soap production have played an inportant role in the history of germicidal and insecticidal agents. Throigh the modern study of structure-function relationships, it has been possible to better identify those lipid products which are most active against microorgcinisns and insects. 

Characterization of cytotoxicity of pyridalyl, an insecticidal agent, to cultured insect and mammalian cells (T. Utsumi, Yamaguchi Univ., Japan)... 

Insecticidal agents, which target at the cholinergic postsynapse. 

Kabara, j. j.. Fatty acids and esters as antimicrobial/insecticidal agents, in Ecology and Metabolism of Plant Lipids (G. Fuller and W. D. Nes, eds.), ACS Symp. Ser. 325,220-238, American Chemical Society, Washington, DC, 1987. 

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