Activity against human immunodeficiency virus

Nonnucleoside reverse transcriptase inhibitor (NNRTI) A noncompetitive inhibitor of the viral reverse transcriptase enzyme that binds to the active site of the enzyme itself, rather than by terminating the enzymatic product. NNRTIs are only active against human immunodeficiency virus-1. 

The addition of sulfated polysaccharides to DCE gels have yielded effective microbicides in vitro, including activity against human immunodeficiency virus (HIV). 

Cycloaddition of a variety of alkynes to the azido function of 3 -azido-2, 3 -dideoxythymidine and 3 -azido-2,3-dideoxyuridine yields products (e.g., 716) with a 1,2,3-triazol-l-yl substituent in the 3 -position (Equation (60)). By contrast to the parent compounds, these triazolyl derivatives have no appreciable activity against human immunodeficiency virus <89JHC1635>. Cycloadditions of 4-azido-6-methyl-2//-pyran-2-one with alkynes leads to triazoles (717) <93JHC317>. 

P. J. Swart, M. E. Kuipers, C. Smit, R. Pauwels, M. de Bethune, E. De Clercq, H. Huisman, and D. K. F. Meijer, Antiviral effects of milk proteins Acylation results in polyanionic compounds with potent activity against human immunodeficiency virus type 1 and 2 in vitro, AIDS Res. Hum. Retroviruses 72 769-775 (1996). 

The 8-aza analogs of the potent antiviral nucleotide analogs 9-[2-(phosphono-methoxy)ethyl]adenine (PMEA) and 9-[2-(phosphonomethoxy)ethyl]gua-nine (PMEG) were evaluated for activity against human immunodeficiency viruses (94MI3). 

Marquez, V. E., Tseng, C. K.-H., Kelley, J. A., et al. (1987) 2, 3 -Dideoxy-2 -fluoro-ara-A. An acid-stable purine nucleoside active against human immunodeficiency virus (HIV). Biochem. Pharmacol., 36, 2719-2722. 

Castanosp ermine has been shown to have in vitro antiviral activity against human immunodeficiency virus (HIV) [99] and human cytomegalovirus (CMV) [100], which is an opportunistic pathogen in AIDS. Alterations in viral coat glycoproteins in the presence of castanospermine are associated with a loss of infectivity. 6-0-acyl derivatives of castanospermine are more potent inhibitors of HIV growth than the natural product with the 6-O-butyryl-derivative (MDL 28,374) currently in clinical trials for AIDS. The lipophilic nature of the acyl derivative improves uptake by cells but the compound appears to be intracellularly converted to castanospermine [101]. 

O-Demethylbuchenavianine (266) was found active against human immunodeficiency virus (EC50 = 0.26 pM), but its cytotoxicity to CEM-SS host cells (IC50 = 0.66 pM) led to a lower... 

Zidovudine has shown activity against human immunodeficiency virus (HIV) consequently, it is used for the treatment of AIDS and AIDS-related complex (ARC). It positively enhanees the survival and improves the quality of life of patients with eomplieations sueh as severe weight loss, fever, pneumocystosis, herpes zoster, herpes or thrush. Beeause it erosses the blood-brain-barrier (BBB), it has a favourable response on the neurological symptoms of AIDS. 

Quinqueginsin, a homodimeric protein (Mr 53 kDa) with inhibitory activity against human immunodeficiency virus (HIV), fungi, ribonuclease, and cell-free translation. Quinqueginsin has been isolated from the roots of American ginseng Panax quinquefolium. The inhibitory action towards HIV-1 reverse transcriptase was potentiated after chemical modification with succinic anhydride [H. X. Wang, T. B. Ng, Biochem. Biophys. Res. Commun. 2000, 269, 203]. 

Strizki, J.M., et al. Discovery and characterization of vicriviroc (SCFI 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus Type 1. Antimicrob. Agents Chemother. 2005, 49, 4911 919. 

The isomeric michellamines A, B, and C are active against human immunodeficiency virus (HTV)-1 and HIV-2 strains. Michellamines A and B, both having identical tetrahydroisoquinoUne structures and different configurations at the biaiy 1 axes, are synthesized by a simultaneous double-coupling of the di-triflate (Eq. A highly hindered... 

Activity Against Human Immunodeficiency Virus (HIV). A sulfate (GE-3-S) prepared by chlorosulfonic acid treatment GE-3, a partially acetylated P(1 - 6)glucan from the lichen Umbilicaria esculenta (Miyoshi) Mink., inhibited the cytopathic effect of HIV in vitro (Hirabayashi et al. 1989). 

DRUGS ACTIVE AGAINST HUMAN IMMUNODEFICIENCY VIRUS... 

DRUGS ACTIVE AGAINST HUMAN IMMUNODEFICIENCY VIRUS NUCLEOSIDE ANALOGUE REVERSE TRANSCRIPTASE INHIBITORS (NRTI) [SED-15, 2586 SEDA-30, 349 SEDA-31, 482 SEDA-32, 534]... 

DRUGS ACTIVE AGAINST HUMAN IMMUNODEFICIENCY VIRUS INHIBITORS OF HIV FUSION [SEDA-28, 337 SEDA-29, 310]... 

Asres K, Bucar F, Kartnig T et al (2001) Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanicaUy selected Ethiopian medicinal plants. PhytotherRes 15 62-69... 

DRUGS ACTIVE AGAINST HUMAN IMMUNODEFICIENCY VIRUS NUCLEOSIDE ANALOGUE REVERSE TRANSCRIPTASE INHIBITORS (NRTI) 415... 

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