Inhalants sensitization

Absorption intestine (50% children, 10% adults), inhalation Sensitive individuals fetus, children, and women of childbearing age Toxicity/symptoms developmental and nervous system, lowered IQ, memory and learning difficulties, behavioral problems Regulatory facts air - 0.5 mg/m3, drinking water 15 jo.g/1, not allowed in paint or automobile gasoline... 

In a study to investigate potential anaphylactic reactions of subjects with confirmed inhalant sensitization to insects, subjects were orally challenged with extracts of mealworm (Tenebrio molitor) and superworm (Zophobas morio). One of three... 

Erythematous (acute atrophic) Patients with HIV, patients on broad-spectrum antibiotics or steroid inhalers Sensitive and painful erythematous mucosa with few, if any, white plaques lesions are generally on dorsal surface of tongue or hard palate, occasionally on soft palate, but any part of mucosa can be involved appear as flat red patches on the palate or atrophic patches on tongue dorsum with loss of papillae. 

The different danger symbols express the fact that the danger to health of skin and inhalation sensitization are not equal. An asthmatic shock resulting from exposure to a respiratory allergen can have fatal effects. These severe reactions are not known from skin allergens. 

Practical experience. Information relevant to classification has to be added, such as known inhalative sensitizing effects and known carcinogenic or reproductively toxic effects on humans. 

Toxicoiogy LD50 (oral, rat) > 5 g/kg, (skin, rabbit) > 5 g/kg low toxicity by ing. and skin contact primary irritant may be irritating to eyes, skin, and if inhaled sensitizer TSCA listed... 

Sensitizing by inhalation Sensitizing by skin contact Carcinogenic categories 1 and 2 category 3... 

Food hypersensitivity is certainly a common problem in early life and may account for the majority of all allergies in infancy. Although anaphylactoid reactions are a relatively common cause of mild asthmatic exacerbations and of chronic urticaria in adults (see subsequent section), most clinicians would consider that inhalant sensitivities and other non-allergic factors become more important in the generation of asthma and eczema by the age of 4 or 5 years. 

Irritant Skin Sensitive Mild eye Irritant Inhalation, mg/m Oral, mg/kg... 

Health and Safety Factors. Butanediol is much less toxic than its unsaturated analogs. It is neither a primary skin irritant nor a sensitizer. Because of its low vapor pressure, there is ordinarily no inhalation problem. As with all chemicals, unnecessary exposure should be avoided. The LD q for white rats is 1.55 g/kg. 

Primary human skin irritation of tetradecanol, hexadecanol, and octadecanol is nil they have been used for many years ia cosmetic creams and ointments (24). Based on human testing and iudustrial experience, the linear, even carbon number alcohols of 6—18 carbon atoms are not human skin sensitizers, nor are the 7-, 9- and 11-carbon alcohols and 2-ethylhexanol. Neither has iudustrial handling of other branched alcohols led to skin problems. Inhalation hazard, further mitigated by the low vapor pressure of these alcohols, is slight. Sustained breathing of alcohol vapor or mist should be avoided, however, as aspiration hazards have been reported (25). 

The membrane enzyme luciferase, responsible for light emission in fireflies, is sensitive to anesthetics (20,21), and the concentrations of inhalational agents which inhibit luciferase are the same as those which cause general anesthesia. Studies of various classes of inhalational agents and luciferase demonstrated that above a certain chain length in a homologous series, a point is reached where higher members are not anesthetic. The same cut-off effect in efficacy is observed in anesthesia (22). This effect is not explainable by Hpid theory. 

Isoflurane is a respiratory depressant (71). At concentrations which are associated with surgical levels of anesthesia, there is Htde or no depression of myocardial function. In experimental animals, isoflurane is the safest of the oral clinical agents (72). Cardiac output is maintained despite a decrease in stroke volume. This is usually because of an increase in heart rate. The decrease in blood pressure can be used to produce "deHberate hypotension" necessary for some intracranial procedures (73). This agent produces less sensitization of the human heart to epinephrine relative to the other inhaled anesthetics. Isoflurane potentiates the action of neuromuscular blockers and when used alone can produce sufficient muscle relaxation (74). Of all the inhaled agents currently in use, isoflurane is metabolized to the least extent (75). Unlike halothane, isoflurane does not appear to produce Hver injury and unlike methoxyflurane, isoflurane is not associated with renal toxicity. 

Desflurane is less potent than the other fluorinated anesthetics having MAC values of 5.7 to 8.9% in animals (76,85), and 6% to 7.25% in surgical patients. The respiratory effects are similar to isoflurane. Heart rate is somewhat increased and blood pressure decreased with increasing concentrations. Cardiac output remains fairly stable. Desflurane does not sensitize the myocardium to epinephrine relative to isoflurane (86). EEG effects are similar to isoflurane and muscle relaxation is satisfactory (87). Desflurane is not metabolized to any significant extent (88,89) as levels of fluoride ion in the semm and urine are not increased even after prolonged exposure. Desflurane appears to offer advantages over sevoflurane and other inhaled anesthetics because of its limited solubiHty in blood and other tissues. It is the least metabolized of current agents. 

The first SRS-A antagonist, FPL-55712 (26) (149), was discovered before the stmctures of the leukotrienes were detemiined. Although this compound is relatively weak as an antagonist and suffers from a very short half-life in vivo, it played an important role both in leukotriene stmcture elucidation and as a model for later antagonists. In work stmcturaHy related to FPL-55712, LY-171883 was developed (27) (150). LY-171883 was evaluated in several clinical trials before development was stopped. Orally adrninistered, LY-171883 blocked slightly the response to aerosol LTD improved pulmonary function (FEV ) in mild asthmatics (151), decreased the sensitivity of asthmatics to cold air-induced bronchoconstriction (152), and significantly reduced the bronchoconstrictor response to inhaled antigen (153). However, in all these studies the beneficial effects were minimal. 

The MSDS (46) for thiophosgene describes it as highly toxic, corrosive lachrymator and moisture sensitive compound. It may be fatal if inhaled, swallowed, or absorbed through the skin. When using this material one should wear the appropriate NIOSH/OSHA-approved respirator, chemical-resistant gloves, safety goggles, and other protective clothing. It should be used only in a chemical fume hood. 

Bromothiophenes are toxic materials by aU routes. Inhalation toxicity of 2-bromothiophene is significant. Ecotoxicity is also noted for these materials, particularly for 2-bromo-3-methylthiophene. 2-Thiophenecarboxaldehyde and the 3-methyl derivative can cause minor irritation to the skin and eyes of rabbits. The former is a sensitizer to guinea pig skin, the latter is not. 2-Acetylthiophene is toxic in aU modes of contact. Severe exposure causes serious inflammation of the lung, damage to many organs, and depression of the central nervous system. 

The first -PDA antiozonants were low molecular weight -diaLkyl-/)-PDAs which caused skin irritations. Current higher molecular weight -dialkyl or A/-alkyl-AT-aryl derivatives are not primary skin irritants. A notable exception is A/-(I-methylethyl)-A7-phenyl-/)-PDA, which causes dermatitis. However, since some individuals are more sensitive than others, antiozonants should always be handled with care (46). When skin contact does occur, the affected area should be washed with mild soap and water. In case of eye contact, flush weU with water. Inhalation of mbber chemicals should be avoided, and respiratory equipment should be used in dusty areas. 

Beryllium, beryllium-containing aUoys, and beryUium oxide ceramic in soHd or massive form present no hazard whatsoever (31). SoHd shapes may be safely handled with bare hands (32) however, care must be taken in the fabrication and processing of beryUium products to avoid inhalation of airborne beryUium particulate matter such as dusts, mists, or fumes in excess of the prescribed workplace exposure limits. Inhalation of fine airborne beryUium may cause chronic beryUium disease, a serious lung disease in certain sensitive individuals. However, the vast majority of people, perhaps as many as 99%, do not react to beryUium exposure at any level (33). The biomedical and environmental aspects of beryUium have been summarized (34). 

Hexametbylpbosphorous triamide (HMPT) [1608-26-0] M 163.2, m 7.2°, b 49-51°/12mm, 162-164°/12mm, d 0.989, n 1.466. It may contain more than 1% of phosphoric triamide. The yellow oil is first distd at atm press then under reduced press and stored under N2. It is air sensitive, TOXIC, should not be inhaled and is absorbed through the skin. [Mark Org Synth Coll Vol V 602 1973.]... 

Exposure effects Inhalation (general) Respiratory irritation Ingestion Skin/eye irritation Skin and respiratory sensitization Mutagenicity Teratogenicity Carcinogenicity ... 

RESPIRATORY SENSITIZER (asthmagen) A substance which can cause an individual s respiratory system to develop a condition which makes it over-react if the substance is inhaled again. Such an individual is sensitized over-reaction is then likely to occur at concentrations of the substance which have no effect on unsensitized persons and lead to characteristic symptoms, e.g. rhinitis (a runny nose), conjunctivitis or in severe cases asthma or alveolitis. 

Indicators of toxicity hazards include LD50, LC50, plus a wide range of in vitro and in vivo techniques for assessment of skin and eye indtation, skin sensitization, mutagenicity, acute and chronic dermal and inhalation toxicity, reproductive toxicology, carcinogenicity etc. 

Beeause the diisoeyanate is used in exeess, there is usually free monomer present. Isoeyanates are hazardous materials particularly upon inhalation and skin contact. Chronic exposure ean lead to sensitization. The adhesives must therefore be used with proper ventilation and should not come in eontact with the skin in the unreaeted state. Vapor monitoring badges for employees and periodie real time vapor monitoring around process equipment is reeommended. 

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