Inflammatory cells recruitment

Chavakis T, Bierhaus A, Al-Fakhri N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Arnold B, Preissner KT, Nawroth PP. 2003. The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins a novel pathway for inflammatory cell recruitment. J Exp Med 198(10) 1507-1515. 

In brief, these findings shed light on the atheroprotective effects of captopril, which remained poorly understood over a long period of time. Specifically, captopril appears to limit atherosclerosis development by preventing EC dysfunction and inhibiting pro-inflammatory cell recruitment into the intima. 

Driscoll, K.E., Carter, J.M., Hassenbein, D.G., and Howard, B., Cytokines and particle-induced inflammatory cell recruitment, Envirow. Health Perspect, 105 (Suppl. 5), 1159-1164, 1997. 

Brini, E., Ruffini, F., Bergami, A., BrambiHa, E., Dati, G., Greco, B., CiriHo, R., Proudfoot, A.E., Comi, G., Furlan, R., Zaratin, P., and Martino, G. (2009) Administration of a monomeric CCL2 variant to EAE mice inhibits inflammatory cell recruitment and protects from demyelination and axonal loss. Journal of Neuroimmunology,... 

Antoine, D.J., et al., Diet restriction inhibits apoptosis and HMGBl oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity. Mol Med, 2010. 16(11-12) p. 479-90. 

Inflammation is considered the key feature of the immune system response to injury. The main symptoms of inflammations are redness, swelling, pain, and heat. The body s immime system commonly controls the inflammation itself When the inflammations become imcon-trollable, the body becomes diseased, leading to chronic discomfort [109]. This chronic inflammation is the major component of various chronic diseases, including inflammatory bowel disease, rheiunatoid arthritis, osteoporosis, and allergies [110,111]. Along with activation and proliferation of inflammatory cells, cytokines and chemokines are produced in excessive quantities in chronic inflammatory diseases. The primary targets of the anti-inflammatory compounds are the inhibition of inflammatory cell recruitment and proinflammatory mediator production [112]. 

Epithelial damage, mucus hypersecrrtion. Smooth muscle hypertrophy, submucosal edema, inflammatory cell recruitment, airway remodcKug, AHR, and asthma symptoms. 

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