Axonal loss

Sprague JE, Everman SL, Nichols DE An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicology 19 427-A41, 1998... 

Siuciak, JA, Clark, MS, Rind, HB, Whittemore, SR and Russo, AF (1998) BDNF induction of tryptophan hydroxylase mRNA levels in the rat brain. J. Neurosci. Res. 52 149-158. Sprague, JE, Everman, SL and Nichols, DE (1998) An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neuro toxicology 19 427-A42. Stock, MJ (1997) Sibutramine a review of the pharmacology of a novel anti-obesity agent. Int. J. Obesity 21 (Suppl 1) S25-S29. 

Memorial In addition to axon loss/atrophy and defects in myelination, the... 

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD 1 ALS model with highest motor neuron death. Proc Natl Acad Sci USA 105, 12599-12604. 

Detmer, S. A., Vande Velde, C., Cleveland, D. W. and Chan, D. C. (2008) Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet 17, 367-375. 

According to the neuropathological investigations, one of the consequences of LA is axonal loss, which may lead to an increase in the water content of the brain WM tissue, thereby increasing ADC values and decreasing FA of the regions of LA. One may, there-... 

MS is an autoimmune disease that attacks the myelin sheath of oligodendrocytes around the neuronal axons. This allows the axonal cytoskeleton to be damaged, bringing about secondary axonal loss and persisting neurological dysfunction. The characteristic pathology is of a lesion or plaque in the CNS white matter, formed by inflammation and demyelination and these can be classified into active, chronic active, or chronic silent plaques [86]. 

The neuropathology of white matter changes seen on brain imaging is variable and includes partial neuronal loss, axonal loss, demyelination and gliosis (Jagust et al. 2008). The mechanisms underlying such changes are uncertain but there are associations with age. 

We do not discuss the axonal forms of CMT, although they may involve secondary demyelination. Axonal loss is also observed in the demyelinating type 1 CMT (Bjartmar et al 1999). There are some rare autosomal recessive forms called CMT4 which are also demyelinating. 

Bjartmar C, Wujek JR, Trapp BD (2003) Axonal loss in the pathology of MS Consequences for understanding the progressive phase of the disease. J Neurol Sci 206 165—171. 

DeVries GH (2004) Crypdc axonal antigens and axonal loss in muldple sclerosis. Neurochem Res 29 1999—2006. 

Steinsapir KD, Goldberg RA, Sinha S, Hovda DA (2000) Mediyl-prednisolone exacerbates axonal loss following optic nerve trauma in rats. Res tor Neurol Neurosci 17 157—163. 

Peripheral neuropathy (axonal loss and demyelination) acute encephalopathy (seizures) cognitive dysfunction... 

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