Pattern-recognition receptors

Pattern recognition receptors (PRRs) are receptors expressed by cells from the innate immune system... 

Pathogen-Associated Molecular Patterns and Pattern Recognition Receptors... 

Rezaei, N., Therapeutic targeting of pattern-recognition receptors, Ini. Immunopharmacol., 6, 863, 2006. 

Kurt-Jones, E.A., et al., Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus, Nat. Immunol. 1, 5, 398, 2000. 

Phagocytosis and encapsulation, in which pathogens are sequestered within several layers of cells, are the predominant cellular immune responses. Genetic and molecular studies have shown that bacterial products are recognized24 and transduced by host cells25 26 by similar pattern recognition receptors and signal transduction pathways in both vertebrates and invertebrates. 

Brown, GD Dectin-1 a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol 2006 6 33-43. 

The common microbial patterns render recognition by organisms and their self/ nonself recognition is based on innate mechanisms. The common microbial patterns include lipopolysaccharides (LPS), mannose, fucose, technoic acid and /V-formyl peptides. These common microbial patterns are called pattern recognition molecules (PRMs) or pattern recognition receptors (PRRs). 

Until recently, most of the attention regarding allograft rejection focused on T cells and acquired immune response. Pattern recognition receptors (PRRs), which sense conserved pathogen-derived molecules that differentiate infectious nonself from self... 

Chavakis T, Bierhaus A, Al-Fakhri N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Arnold B, Preissner KT, Nawroth PP. 2003. The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins a novel pathway for inflammatory cell recruitment. J Exp Med 198(10) 1507-1515. 

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