INFERGEN interferon

Infergen Interferon acon-1 Amgen Treatment of chronic hepatitis... [Pg.694]

Infergen (interferon alfacon-1 or consensus interferon) is an engineered interferon recently approved for the treatment of hepatitis C (Table 8.8). The development of infergen entailed initial sequence comparisons between a range of IFN-as. The product s amino acid sequence reflects the most frequently occurring amino acid residue in each corresponding position of these native interferons. A DNA sequence coding for the product was synthesized and inserted into E. coli. The recombinant product accumulates intracellularly as inclusion bodies. [Pg.228]

Infergen (interferon acon-1, or consensus interferon) is an engineered IFN recently approved for the treatment of hepatitis C (Table 4.8). The development of Infergen entailed initial... [Pg.211]

INFERGEN (interferon alfacon-1) [E. coli-expressed recombinant protein]... [Pg.318]

Infergen Interferon alfacon-l Amgen 10/1997 Chronic hepatitis C virus (HCV) infection E. coli... [Pg.1423]

INFERGEN (interferon alfacon-1) E. coli-expressed recombinant protein] (InterMune) CFP Farma-ceutica (European Union) Amgen (U.S.) Liquid 9 pg singledose vials or 15 pg single-dose vials 9 pg in 0.3 mL 15 pg in 0.5 mL (pH 7.0 0.2) Per vial 5.9 mg/mL sodium chloride 3.8 mg/mL sodium phosphate... [Pg.318]

Intermune. Infergen (Interferon alfacon-1). Available http //www.infergen.com/pdf/ infergen pi.pdf. Accessed July 26, 2005. [Pg.833]

Interferon alfa-2a (Roferon A), interferon alfa-2b (Intron-A), and interferon alfacon-1 (Infergen) are approved for chronic hepatitis C. However, they are not prescribed alone because only 12% to 16% of patients achieve a sustained virologic response (SVR). Adding ribavirin, a synthetic guanosine analogue that inhibits viral polymerase, increases the SVR rate to 35% to 45%. [Pg.356]

Infergen (rIFN-a, synthetic type I interferon) Amgen (USA) Yamanouchi Europe (EU) Chronic hepatitis C... [Pg.209]

B. Indications and nse Infergen is indicated for treating chronic hepatitis C virus (HCV) infection in adults with compensated liver disease who have anti-HCV serum antibodies and/or the presence of HCV RNA. It is also effective in the subsequent treatment of patients who did not respond or relapsed after initial interferon therapy. In some patients with chronic HCV infection, Infergen normalizes serum alanine aminotransferase (ALT) concentrations, reduces serum HCV RNA concentrations to undetectable quantities (<100 copies/ml), and improves liver histology. [Pg.188]

Pharmacokinetics The pharmacokinetic properties of Infergen have not been evaluated in patients with chronic hepatitis C. Pharmacokinetic profiles were evaluated in normal, healthy volunteer subjects after subcutaneous injection of interferon alfacon-1 at doses up to 9 j,g. Plasma levels of interferon alfacon-1 at any dose were too low to be detected. However, analysis of Infergen-induced cellular products— induction of 2 5 oligoadenylate synthetase and (beta)-2 microglobulin—after treatment in these subjects revealed a statistically significant, dose-related increase in the area under the curve (AUC). [Pg.189]

E. Therapeutic response Efficacy of Infergen therapy was determined by measurement of serum alanine aminotransferase (ALT) concentrations at the end of therapy (24 weeks) and following 24 weeks of observation after the end of treatment of adults with chronic HCV infection. Serum HCV RNA was also assessed using a quantitative reverse transcriptase polymerase chain reaction (RT-PCR). At the end of 24 weeks of treatment, ALT normalization was observed in 39% of patients on Infergen and in 35% of patients on interferon alfa-2b Intron A). Only 17% of patients in each group... [Pg.189]

Interferons and cytokines Interferon alfacon-1, human recombinant, produced in E. coli Infergen Sterile solution, SDV and prefilled syringes containing 9 j,g in 0.3 ml or 15 j,g in 0.5 ml SC... [Pg.461]

Parenteral 5 million IU/vial Interferon alfacon-1 (Infergen)... [Pg.1089]

Interferon alfa con-1 Infergen (InterMune) Hepatitis C (Naive and Relapse)... [Pg.271]

USA interferon alfacon-1 interferon Infergen Advaferon, Inferax Recombinant consensus human lymphoblast interferon alpha expressed in E. coli Antiviral... [Pg.471]

Interferon alfacon-1 Infergen, CIFN Modified interferon (166 amino acids)... [Pg.231]

The client diagnosed with chronic hepatitis C who is taking interferon alfacon (Infergen), an antiviral medication, reports having fever, muscle pain, and headaches to the nurse. Which action should the nurse take ... [Pg.108]

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