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Ligand Binding Domains

Forty-four amino acid module characterized by three internal disulfide bridges and an octahedrical cage for a calcium ion. Complement-type repeats are found in many cell surface proteins and form the ligand-binding domain of receptors of the LDL receptor gene family. [Pg.385]

SHRs are built in a modular structure with similar structure elements. They contain a DNA-binding domain (DBD), a hinge region with a nuclear location signal (NLS), a ligand-binding domain (LBD) and several transcriptional activation functions (Fig. 1). [Pg.1126]

In the monoamine receptors the ligand-binding domain is located within the transmembrane helices. A pocket is formed between TM3, TM5 and TM6 where the agonist binds. A conserved aspartate residue in TM3 (Asp-113 in the /(-adrenoceptor) and a... [Pg.70]

Jacobsson, K., and Frykberg, L. (1995). Cloning of ligand-binding domains of bacterial receptors by phage display. BioTechniques 18, 878-885. [Pg.115]

Brejc, K., van Dijk, W. J., Klassen, R. V., Schuurmans, M., van der Oost, J., Smit, A. B., and Sixma, T. K., Crystal structures of an ACh-binding protein reveal the ligand-binding domain of nicotinic receptors, Nature, 411, 269-276, 2001. [Pg.129]

STRUCTURAL STUDIES OF RECEPTOR TYROSINE KINASES 4.5.1 Ligand-Binding Domains... [Pg.136]

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Glucocorticoid receptor ligand-binding domain

Hormone receptor ligand-binding domains

LBD, Ligand-binding domain

Ligand binding domaine

Ligand binding domaine

Ligand binding domains, nAChR

Ligand-binding cavities, domain

Ligand-binding domains receptor tyrosine kinases

Ligand-binding extracellular domain

NAChR receptor ligand binding domains

Nuclear hormone receptors ligand-binding domains

Nuclear receptor Ligand binding domain

Receptor superfamilies extracellular ligand binding domains

Retinoic acid ligand binding domains

Retinoic acid receptor ligand binding domain

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