Induced hypersensitive lesion

Oral corrosion of metallic restorations does not, per se, generally result in serious damage to the structure. Corrosion can result, however, in various local and systemic effects, notably the hypersensitivity and allergic reactions reported by many workers. Galvanic cells created by mixed metal couples can delay fracture healing and induce oral lesions and cancer. 

Cells deficient in DNA repair are hypersensitive to cisplatin and some cisplatin-resistant cell lines show increased DNA repair and increased expression of the DNA. Platinum-induced DNA lesions are primarily repaired by the NER system. This system involves more than 20 proteins responsible for damage recognition, incision of the DNA strand on both sides of the lesion, removal of the damaged bases, and finally ligation by a DNA ligase. 

Skin Of 320 patients, 24 (7.5% 95% Cl = 4.7, 11) had heparin-induced skin lesions, which were delayed-type hypersensitivity reactions in all cases [110 ]. The... 

Pain at the injection site is one of the most commonly reported adverse effects of vaccination. The reaction is usually mild with complaints of pain and tenderness at the injection site that may or may not be accompanied by erythema. Local reactions tend to be more frequent with repeated doses or booster doses of vaccine. The frequency and degree of the reactions appear to be related to the amount of preformed antibodies and rapid immunologic responses reflective of priming from previous doses. More serious Arthus reactions are infrequently reported. Arthus reactions are classified as type III hypersensitivity reactions, and are characterized by a massive local response involving the entire thigh or deltoid. Arthus reactions are also related to preformed antibody complexes that induce an inflammatory lesion.14... 

Ingested arsenic localizes to the skin [2, 7], where it may alter cutaneous immune responses. The delayed type hypersensitivity (DTH) response to 2,4-dinitrochlorobenzene (DNCB) was suppressed in Bowen s disease patients [8], Langerhans cells (LC) in skin lesions and perilesioned skin from arsenic-induced Bowen s disease and carcinomas were reduced in number and were morphologically altered, having a notable loss of dendrites [9], These data suggest that chronic exposure to arsenic in drinking water may... 

Cutaneous vasculitis is often a feature of such cases, although severe systemic manifestations often also occur. Two patients with propylthiouracil hypersensitivity presented with skin manifestations but also had renal, rheu-matological, and hematological features (66). A review of the literature showed that the symptoms and signs in patients with ANCA-associated thionamide-induced vasculitis are diverse. Acral purpuric skin lesions are typically seen recognition of these classical clinical features may allow early diagnosis and limit associated morbidity and the requirement for other therapies, particularly immunosuppression. Several other reports have described... 

Hypersensitivity reactions are rare, but a few have been reported after inhalation. Delayed hypersensitivity reactions, particularly affecting vascular tissue, have been recorded with chronic systemic administration. Tumor-inducing effects are difficult to attribute to cannabis alone. Animal studies have shown neoplastic pulmonary lesions superimposed on chronic inflammation, but such pathology may be primarily associated with the tar produced by burning marijuana. The most serious potential adverse effects of cannabis use come from the inhalation of the same carcinogenic hydrocarbons that are present in tobacco, and some data suggest that heavy cannabis users are at risk of chronic respiratory diseases and lung cancer. 

Rhinitis, bronchospasm, and asthma can occur as a manifestation of hypersensitivity to penicillamine (SEDA-5, 248) (61-63) and rarely of the Churg-Strauss syndrome (64). Rhinitis can also be a symptom of peni-ciUamine-induced pemphigus (65). In one patient a large pulmonary cyst developed concomitantly with skin lesions characteristic of the use of large doses of penicillamine (66). Microscopic derangement of the elastic fibers predominated. Although the frequency is uncertain, penicillamine can be associated with recurrent respiratory tract infections, that is secondary to IgA deficiency (67,68) or as part of the yellow nail syndrome (SEDA-9, 223). 

Cobalt is an essential element. Its deficiency can result in pernicious anemia. It is present in vitamin B12. Excessive intake of this element may result in polycythemia or overproduction of erythrocytes and heart lesions. Exposure to its dusts can produce cough and respiratory irritation. Chronic inhalation of its dusts or fumes can decrease pulmonary functions and may cause diffuse nodular fibrosis and other pulmonary diseases. Skin contact may induce dermal hypersensitivity reactions, producing an allergy-type dermatitis. 

Perez-Padilla R, Gaxiola M, Salas J, et al. Bronchiolitis in chronic pigeon breeder s disease. Morphological evidence of a spectrum of small airway lesions in hypersensitivity pneumonitis induced by avian antigens. Chest 1996 110(2) 371-377. 

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