DNA Damage Recognition

Hartman AR, Ford JM. BRCAl induces DNA damage recognition factors and enhances nucleotide excision repair. Nat Genet 2002 32 180-184. 

However, much data has been accumulated in recent years indicating that the replication machinery can elongate past cisplatin-DNA lesions in a mutagenic way [15], Intervention of specific DNA polymerases and protein-protein interactions between replicative enzymes and DNA damage-recognition proteins may lead to occasional translesion DNA synthesis. This translesion synthesis can occur in an error-prone fashion, leading to indue-... 

Van Houten, B., Croteau, D. L., Della Vecchia, M. J., Wang, H., and Kisker, C. Close-fitting sleeves DNA damage recognition by the UvrABC nuclease system. Mutat. Res. 577, 92-117, 2005. 

The altered structure of the DNA duplex attracts proteins involved in DNA damage recognition and high-mobility group domain (HMG) proteins, which have been postulated to mediate the antitumor activity of cisplatin. 

The type of base modification will determine which protein will come first and which system, BER or NER, will be used to cure the damaged DNA. NER is responsible for the removal of bulky adducts such as dimerized pyrimidine bases produced by UV radiation from sunlight, or benzo(a)pyren or psoralen adducts and others (Tab. 1). Bulky adducts are Table 1. Radiation-induced DNA damage recognition proteins in human cells. 

Hosfield DJ, Daniels DS, Mol CD, Putnam CD, Parikh SS, Tainer JA (2001) DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes. Prog Nucleic Acid Res Mol Biol 68 315-47... 

The intricate structural chemistry of base excision repair machinery implications for DNA damage recognition, removal, and repair. DNA Repair, 6, 410-428. 

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell, 135, 1213—... 

Wood, R.D. (1999) DNA damage recognition during nudeotide exdsion repair in mammalian cells. Biochemistry, 81, 39-44. 

Dip, R., Camenisch, U., and Naegeli, H. (2004) Mechanisms of DNA damage recognition and strand disdimination in human nucleotide exdsion repair. DNA Repair, 2,1409-1423. 

Sugasawa, K., Shimizu, Y., Iwai, S., and Hanaoka, F. (2002) A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair,... 

DNA Damage recognition as the first step in excision repair of the Pt/DNA lesion... 

Reardon, J. T., and Sancar, A. (2004). Thermodynamic cooperativity and kinetic proofreading in DNA damage recognition and repair. Cell Cycle. 3, 141—144. 

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