Inadequate control

Typically NO conversion ranges from 80 to 95% and there are corresponding decreases in CO and hydrocarbon concentrations. Potential problems associated with NSCR appHcations include catalyst poisoning by oil additives, such as phosphoms and 2inc, and inadequate control systems (37). 

Number of inadequately controlled risks identified and corrected, along with the appropriate allocation of capital to risk reduction activities... 

Platelets play an important role in hemostasis and are involved in the pathogenesis of many diseases, such as artherosclerosis and asthma. Moreover, an inadequately controlled aggregation may lead to vascular occlusion. 

Shows the margin of safety available to short-term creditors. Significantly higher ratios than 2 1 may indicate excess stocks, poor credit control or inadequate control of cash resources. 

Malfunctions of small arms ammo using the M34 primer have been related to inadequate control of pellet wt in the primer, with low pellet weight causing hangfires in the weapon. At the Army Mechanics and Materials Research Center (AMMRC), Watertown, Mass, NAA was investigated for 100% inspection of pellet wt in such primers (Refs 5 6)... 

From this survey it is clear that just as normal neuronal function requires appropriately balanced inhibitory and excitatory controls so the generation of interictal spikes depends on disturbances in both. Clearly activity cannot spread without the activation of excitatory circuits, in which NMDA receptors play an important role, but it will be much facilitated by reduced inhibition (Masukawa et al. 1989). These observations may help to explain the establishment of a focus and the development of the interictal spike, but why activity can only spread to seizure proportions, at certain times, is less clear. It will, however, again require overactivity of excitatory circuits inadequately controlled by inhibitory processes. Since these controls are mediated by... 

Excessive use of inhaled short-acting (J2-agonists is an indicator of inadequately controlled asthma. 

Dopamine agonists are useful as initial therapy, as they can delay the need to start levodopa and can decrease the risk of developing motor fluctuations by two- to threefold during the first 4 to 5 years of treatment. After a few years, dopamine agonists inadequately control the patient s symptoms and levodopa needs to be started. In advanced disease, dopamine agonists can be added to levodopa because they have a longer duration of action, minimize fluctuations in dopamine blood concentrations, decrease off-time, improve wearing-off symptoms, allow a reduction in levodopa dose, and improve ADLs.1-3,16,22,23,26... 

If a patient has inadequate control on two drugs, adding a third class can be considered (e.g., a glitazone, exenatide, a dipeptidyl peptidase-IV inhibitor, or basal insulin). Therapy should be guided by the A 1C, FPG, cost, additional benefits (e.g., weight loss), and avoidance of side effects). 

Caution Increasing use of beta-agonist or use >2 times a week for symptom control (not prevention of EIB) indicates inadequate control and the need to step up treatment. 

Leukotriene receptor antagonists also are successful as additive therapy in patients inadequately controlled on inhaled corticosteroids alone and as corticosteroid-sparing therapy. However, the magnitude of these benefits is less than that reported with the addition of long-acting fi2-agonists. 

Because of its high cost, it is only indicated as step 5 or 6 care for patients who have allergies and severe persistent asthma that is inadequately controlled with the combination of high-dose inhaled corticosteroids and long-acting /f2-agonists. 

Shafer et al. (2005) [53] reviewed 22 studies for DNT of pyrethroids including the above studies and summarized them. They insisted that additional, well-designed and well-executed DNT studies are needed because most of the studies suffered from inadequate design, problematic statistical analyses, use of formulated products, and/or inadequate control. 

Notwithstanding the intellectual challenges posed by the subject, the main impetus behind the development of computational models for turbulent reacting flows has been the increasing awareness of the impact of such flows on the environment. For example, incomplete combustion of hydrocarbons in internal combustion engines is a major source of air pollution. Likewise, in the chemical process and pharmaceutical industries, inadequate control of product yields and selectivities can produce a host of undesirable byproducts. Even if such byproducts could all be successfully separated out and treated so that they are not released into the environment, the economic cost of doing so is often prohibitive. Hence, there is an ever-increasing incentive to improve industrial processes and devices in order for them to remain competitive in the marketplace. 

Many millions of tons of useful products and substances are safely made by chemical reactions each year. Nevertheless, intended reactions can lead to major loss events if inadequately controlled. The following is an example of a chemical reactivity incident in a process with intentional chemistry (EPA 1999a). 

Present status Invasive, i.e., requires withdrawing of blood Infrequent measurements result in blood glucose variations Long-term health consequences result from inadequate control of blood sugar... 

Some occupational situations, if inadequately controlled, can create opportunities for damage to the respiratory system. Exposure to certain forms of the metals nickel and cadmium, ordinarily as airborne particulates, can cause cellular damage, edema, and, if sustained for sufficiently long periods, emphysema. Many other metals, usually only in some of their many chemical forms, can produce emphysema upon subchronic or chronic exposure. 

Clozapine is an atypical antipsychotic that is usually used in patients who are inadequately controlled with other antipsychotics. The reason is that clozapine is associated with a risk of potentially fatal agranulocytosis. As with other atypicals, side-effects of clozapine include occurrence of hyperglycaemia and diabetes. 

Any biological deterioration of cellulose acetate membranes is always by "accidental". To prevent this kind of deteriorations, chlorine injection to feed water is common practice. Inadequate control of chlorine injection may result in the enzymic deterioration of cellulose acetate membrane. 

In a case-control study of workers in various wood industries, an increased risk for tumors of the mouth and respiratory tract was associated with phenol exposure however, the small number of cases and confounding exposures were inadequately controlled." The lARC has determined that there is inadequate evidence for carcinogenicity of phenol in humans and experimental animals and that it is not classifiable as to its carcinogenicity to humans. ... 

Combination therapy - In patients whose hyperglycemia is inadequately controlled with metformin or after a therapeutic response to a thiazolidinedione, nateglinide may be added to, but not substituted for, metformin. 

Starting dose for patients inadequately controlled on metformin monotherapy -Based on the usual starting dose of pioglitazone (15 to 30 mg daily), pioglitazone/metformin may be initiated at either the 15 mg/500 mg or 15 mg/850 mg tablet strength once or twice daily, and gradually titrated after assessing adequacy of therapeutic response. 

Patients inadequately controlled on metformin monotherapy - Starting dose is 4 mg rosiglitazone (total daily dose) plus the dose of metformin already being taken (see table). 

Patients who remain severely disturbed or inadequately controlled may require dosage adjustment. Daily dosages up to 100 mg may be necessary. Infrequently, doses more than 100 mg have been used for severely resistant patients however, safety of prolonged administration of such doses has not been demonstrated. 

WARNING Rqx>rts of anaphylaxis 2—24 h after administration, even in previously treated pts Uses Mod-sevCTe asthma in >/=12 y w/ reactivity to an all gen when Sxs inadequately controlled w/ inhaled st oids Action Anti-IgE Ab Dose 150-375 mg SQ q2-4wk (dose/frequency based on SCTum IgE level BW, see package insert) Caution (B, /-] Contra Component aU gy, acute bronchospasm Disp Inj SE Site Rxn, sinusitis, HA, anaphylaxis rqwrted in 3 pts Interactions May X effectiveness OF vaccines and T tox OF hve vaccines may T natalizumab Infxn tox EMS Not for acute asthma, use inhaled J-agonists allergic Rxns are common OD Unlikely to cause hfe-threatening Sxs, exc t for aU gic Rxn... 

Charbonel B, Karasik A, Ji Liu, Mei Wu, Meininger G, for the Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 2006 29 2638-43. 

Moderate to severe persistent asthma in patients who are reactive to a perennial allergen and whose asthma symptoms have Been inadequately controlled with inhaled corticosteroids Subcutaneous 150-375 mg every 2 or 4 wk dose and dosing frequency are individualized based on weight and pretreatment IgE level (as shown below). 

It is used as first line therapy in NIDDM inadequately controlled by diet and as adjunct to existing conventional oral hypoglycemic agents where hypoglycemic control is inadequate. 

B. Indications and use Insulin is indicated for all patients with type 1 diabetes mellitus and for patients with type 2 diabetes mellitus who are inadequately controlled by oral medication. 

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