In vivo behaviour

Pego AP, Luyn MJAV, Brouwer LA, et al. In vivo behaviour of poly (1,3-trimethylene carbonate) and copolymers of 1,3-trimethylene carbonate with D,L-lactide or e-caprolactone Degradation and tissue response. J Biomed Mater Res, 2003, 67A, 1044—1054. 

The competitive equilibria based on the different plasma models cannot solely explain the in vivo behaviour of Gd111 complexes. The excretion of low molecular weight Gd111 chelates from the body is very rapid (e.g., t1/2 = 1.6 h for [Gd(DTPA)]2 ),M0 whereas the dissociation and trans-metallation of the Gd111 complexes is relatively slow. Therefore, the system is far from equilibrium and kinetic factors could substantially change the predicted amount of free Gd3+. 

J. M. Irache, M. Berrabah, P. Verite, and S. Menager, Phenobarbitone-loaded poly-curly epsilon-caprolactone nanocapsules In vitro kinetics and in vivo behaviour by the oral route, in Formulation of Poorly-Available Drugs for Oral Administration, Paris, 1996, pp. 334-337. 

G. Digenis, The in vivo behaviour of multiparticulate versus single unit dose formulations, Capsugel Symposium, Seoul and Tokyo, 1990. 

K. Lehmann, B. Brogmann, C. J. Kenyon, J. R. Wilding, The in vivo behaviour of enteric naproxen tablets coated with an aqueous dispersion of methacrylic acid copolymer, S.T.P. Pharma Sci 7(6) 403-437 (1997). 

F]FDT, 117, has been prepared16221 as shown in equation 72. Non-radioactive product has also been prepared in 53% yield by the fluorination of 118 with Me4NF followed by deprotection with BBr3. The in vivo behaviour of 118 in tumour-bearing animals had a... 

Some factors that influence the sensitivity and degree of in vitro-in vivo correlations are shown in Scheme 12.1. Some relate to the dissolution method, some to the dosage form and some, of course, to in vivo behaviour. 

Many other tests could have been included to demonstrate the value of in vitro tests in quality control. Some, such as multistage impingers for aerosols, can be predictive of in vivo behaviour, or at least give an assurance of consistency of effect. An interesting test system for evaluating inhaled nasal delivery systems (Fig. 12.18) combines a physical device with cultured cells so that the interaction of microparticles with living cells can be studied directly. As new delivery systems appear, new tests will be required - as will ingenuity. 

Studies of classic bone seeking substrates were performed to assess the labelling yield and stability of the preparations. Biodistribution experiments were also carried out with these radionuclides. One of the main advantages of our group is the permission to use spontaneous animal tumours for radiopharmaceutical research, which offers the possibility to evaluate the in vivo behaviour of radiopharmaceuticals. Therefore, HEDP was labelled with EDTMP with Lu and DMSA(V) with i Re. 

Actually, the determination of the receptor-kinetics (pharmacodynamics) of a digitalis compound Table 4.6) can be indispensable for the understanding of its in vivo behaviour as shown for the above-mentioned 16a-hydroxy-digitoxin [51,254]. Naturally, knowledge of the dynamics of interaction will also make possible the more profound interpretation of the thermodynamic equilibrium data given in Tables 4.1-4.5. 

Leclercq, L., Boustta, M., Vert, M. A physico-chemical approach of polyanion-polycation interactions aimed at better understanding the in vivo behaviour of polyelectrolyte-based drug delivery and gene transfection. J. Drug Target. 2003,11 (3), 129-138. 

Brown, K.J., Atkinson, J.R., Dowson, D. and Wright, V. (1976) The wear of ultra high molecular weight polyethylene and a preliminary study of its relation to the in vivo behaviour of replacement hip joints. Wear, 40, 255-264. 

In order to further understand the effect of sizes and surface coatings on the in vivo behaviour of GO, three GO samples, including ultrasmall nGO-PEG ( 23 nm) with covalent PEG coating, ultrasmall nRGO-PEG ( 27 nm). 

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