In humans structure

Colizza, K, Awad M, Kamel A. Metabolism, pharmacokinetics, and excretion of the substance preceptor antagonist CP-122,721 in humans Structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by high-performance liquid chromatography—tandem mass spectrometry and NMR spectroscopy. Drug Metab Dispos 2007 35(6) 884—897. 

Zhang, K.E. Wu, E. Patick, A.K. Kerr, B. Zorbas, M. Lankford, A. Kobayashi, T. Maeda, Y. Shetty, B. Webber, S. Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans Structural identification, levels in plasma, and antiviral activities, Antimicrob.Agents Chemother., 2001,45, 1086-1093. [LC-MS reserpine is internal standard LOQ 20 ng/mL]... 

A third perspective emphasizes the culture in cultural landscapes. Such an approach is able to harvest meaning from large-scale constructions by explicitly regarding the landscape as a set of cultural messages written in human structures, by approaching the landscape as a text. 

In biological systems molecular assemblies connected by non-covalent interactions are as common as biopolymers. Examples arc protein and DNA helices, enzyme-substrate and multienzyme complexes, bilayer lipid membranes (BLMs), and aggregates of biopolymers forming various aqueous gels, e.g, the eye lens. About 50% of the organic substances in humans are accounted for by the membrane structures of cells, which constitute the medium for the vast majority of biochemical reactions. Evidently organic synthesis should also develop tools to mimic the Structure and propertiesof biopolymer, biomembrane, and gel structures in aqueous media. 

M. G. J. Beets, SAR Structure—Activity Relationships in Human Chemoreception, AppHed Science Pubhshers, London, 1978. 

The penicillins are a class of compound having the general structure (1). Because of their unique effectiveness in the treatment of bacterial infections in humans, these compounds have been investigated intensively from the chemical, microbiological and clinical points of view since about 1940. The early history of these developments (see especially B-80MI51100, B-49MI51100) contains the following pivotal studies ... 

The role of nails in human metabolism is still the unexplored field. Nowadays, on the literature sources, there is no information about elemental content of each nail of individual human. There is a little information about how the elements to get into the nail structure. Weather it is possible the exogenous elements to enter the nail or no How the elements to distribute in different nails of the same individual How the elements to distribute on the total area of nail Weather the changes in elemental composition in time take place. 

Pedersen, O. M. (1985). Human Risk Contributions in the Process Industry Guides for their Pre-Identificationx in Well-Structured Activities and for Post-Incident Analysis. Report No. RIS0-M-2513, Riso National Laboratories, Roskilde, Denmark. 

Farnesyl transferase from rat cells is a heterodimer consisting of a 48 kD u-snbnnit and a 46 kD /3-snbnnit. In the structure shown here, helices 2 to 15 of the u-snbnnit are folded into seven short coiled coils that together form a crescent-shaped envelope partially surrounding the /3-snbnnit. Twelve helices of the /3-snl> nnit form a novel barrel motif that creates the active site of the enzyme. Farnesyl transferase inhibitors, one of which is shown here, are potent suppressors of tumor growth in mice, but their value in humans has not been established. 

Human and horse insulin both have two polypeptide chains, with one chain containing 21 amino acids and the other containing30 amino acids. They differ in primary structure at two places. At position 9 in one chain, human insulin has Ser and horse insulin has Gly at position 30 in the other chain, human insulin has Thr and horse insulin has Ala. How must the DNA for the two insulins differ ... 

Gem, see Geminal, 705 Geminal (gem), 705 Genome, size of in humans. 1107 Gentamicin, structure of, 1002 Geraniol, biosynthesis of, 382 Geranyl diphosphate, biosynthesis of, 1077-1078... 

Camptothecin was discovered as an active anticancer drug isolated from the bark of Camptotheca acuminata. The anticancer activity of camptothecin was discovered in the 1960s by the National Cancer Institute (NCI) as part of a systematic effort to screen for novel anticancer agents derived from natural products. Monroe Wall and Mansuhk Wani identified the chemical structure of camptothecin. They also identified the chemical structure of taxol, again under the auspices of the NCI. Susan Hoiwitz was contracted by the NCI to elucidate the anticancer mechanisms of camptothecin. She found in the early 1970s that camptothecin induced DNA breaks and attested DNA and RNA synthesis. However, it is approximately 12 years later, only after DNA topo-isomerase I (Topi) had been identified in human cells, that Leroy Liu and his coworkers found that Topi was the cellular target of camptothecin [reviewed in [1]. 

The disruption of C1C-2 in mice leads to male infertility, blindness, and leukodystrophy, and was attributed to defective extracellular ion homeostasis in narrow clefts. C1C-2 yields currents that slowly activate upon hyperpolarization. It is also activated by cell swelling and by extracellular acidification. Structural determinants that are essential for these types of activation were identified by mutagenesis. There is a report that C1C-2 might be mutated in human epilepsy, but this has not been confirmed in fiuther studies. 

In humans and mice, the FATP family is comprised of six structurally related members (FATP 1-6 33-57.1%... 

Frizzled (Fz) proteins comprise a family of seven-pass transmembrane receptors with a cysteine-rich extracellular domain. As a class, Fz proteins are structurally related to the superfamily ofheterotrimeric G-protein coupled receptors (GPCRs). Diere are 4 Fz genes in Drosophila and 10 in humans, with close orthologs... 

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