IgE receptors

D, Kinet JP, Stingl G The high affinity IgE receptor (FceRI) mediates IgE-dependent allergen presentation. J Immunol 1995 154 6285-6290. 

Our understanding of anaphylaxis has advanced substantially since the original description of this phenomenon in the scientific literature over 100 years ago. There is now little reasonable doubt that the IgE-dependent activation of mast cells and basophils is the key event underlying most examples of allergen-induced anaphylaxis in humans [3-5]. IgE binds to the high-affinity IgE receptor, FcsRI, expressed on the... 

MacGlashan D Jr IgE receptor and signal transduction in mast cells and basophils. Curr Opin Immunol 2008 20 717-723. 

Spiegel DE. Tucker J. Battaile JT. Alevy Y, Yan L. Agapov E. Kim EY. Holtzman MJ Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 2007 204 2759-2769. 37... 

Lichtenstein LM IgE receptors on human basophils. 60 relationship to serum IgE concentration. J Clin Invest 1978 62 176-181. 

Hide M, Francis DM, Grattan CEH, Hakimi J, Kochan JP, Greaves MW Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 1993 328 1599. Sd... 

Basophil selection cells with high-affinity IgE receptors... 

Louahed, J., Kermouni, A., van Snick, J. and Renauld, J.C. (1995) IL-9 induces expression of granzymes and high affinity IgE receptor in murine T helper cell clones. Journal of Immunology 154, 5061-5070. 

Lorentz, A., Schwengberg, S., Sellge, G., Manns, M.P. and Bischoff, S.C. (2000) Human intestinal mast cells are capable of producing different cytokine profiles role of IgE receptor cross-linking and YEA. Journal of Immunology 164, 43-48. 

Torn, H., Pawankar, R., Ra, C., Yata, J. and Nakahata, T. (1998) Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking enhanced ILrl3 production by IU4-primed human mast cells. Journal of Allergy and Clinical... 

Stump, R.F., Pfeiffer, J.R., Schneebeck, M.C., Seagrave, J.C., and Oliver, J.M. (1989) Mapping gold-labeled receptors on cell surfaces by backscattered electron imaging and digital image analysis Studies of the IgE receptor on mast cells. Am. J. Anat. 185, 128-141. 

Saturation of the IgE-receptor by IgE or the removal of cell-bound IgE, has no observable effect on peptide stimulation of histamine secretion [86a]. 

One of the distinctive features of basophils is that they possess plasma membrane IgE receptors (FceR), which bind the fragment crystallisable (Fc) region of IgE with high affinity. This is in contrast to the FceR on lymphocytes and macrophages, which binds IgE with only low affinity. 

SHIP SH2 domain binds to the phosphorylated mM (p-ITIM) of other inhibitory co-receptors (gp49Bl) (Kuroiwa etal, 1998) and to the p-ITIM-like motif of the adhesion receptor, PECAM-1 (Pumphrey et al., 1999), furthermore, in vitro it binds to the phosphorylated immimoreceptor tyrosine based activation motifs (p-TTAM) within the p and y subunits of the high affinity IgE receptor (Kimura et al. 1997)), and the zeta chain of T cell receptor (Osborne et al, 1996). However, in vivo coprecipitation of these molecules was not observed. 

Kimura T., Sakamoto, H., Appella, E., and Siraganian, R.P. 1997. The negative signaling molecule SH2 domain containing inositol polyphosphate 5-phosphatase (SHIP) binds to the tyrosine phosphorylated P subunit of the high affinity IgE receptor. J. Bio.Chem. 272 ... 

Osborn, M.A., Zenner,G., Lubinus M., Zhang X., Songyang, Z., Cantley, L.C., Majerus, P., Bums, P., and Kochan, J.P., 1996, The inositol 5-phosphatase SHIP binds to the mmunoreceptor signahng motifs and responds to high affinity IgE receptor aggregation. J. Biol. Chem. 271 29271-29278. 

Fig. 1. Transmission electron micrograph of RBL-2H3 cells with colloidal gold conjngated to a monoclonal antibody against the IgE receptor. (A) Gold con-jngate is localized primarily in coated pits. (B) Five minntes after exposing cells to antibody-coated gold, gold particles are localized in early endosomes. Bar = 0.5 pm.

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