Presence of IgE Receptors on Eosinophils

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In the mouse, in striking contrast with both the human and the rat situations, the absence of FceR, even on eosinophils present in granuloma from Schisto-rawfl-infected animals, was unambiguously demonstrated (27). 

Galectin-3 (MAC-2/e-BP) was first identified on macrophages (28), then on mast cells (29) and neutrophils (30). Expression of galectin-3 (MAC-2/e-BP) was also detected at the surface of human eosinophils (31). An inhibition of IgE-dependent eosinophil-mediated cytotoxicity towards parasite targets by anti-Mac-2 mAb was observed, reflecting a functional role of this IgE binding structure. 

Galectin-3 mRNA was detected in mouse eosinophils (27). Disruption of galectin-3 gene in mice has been shown to reduce macrophage-mediated peritoneal inflammation and seems to be involved in chemoattraction of monocytes and macrophages (32). 

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