IgE receptors eosinophils

The controversies concerning eosinophil IgE receptors have taught us several important lessons. Eirst, transcription of mRNA or even the presence of synthesized receptor protein within the cells does not necessarily indicate the expression of the receptor on cell surfaces. Potential discrepancies between receptor expression and actual receptor function need to be resolved. 

Eosinophils express receptors for IgA (Abu-Ghazaleh et /., 1989), IgG (CD32, CD16 Hartnell et id., 1990, 1992 Valerius et al., 1990) and IgE (FccRI and FccRII-CD23 Capron et al., 1992 Gounni et al., 1994). Peripheral eosinophils ftom aUeigic rhinitic and asthmatic... 

Gounni, A.S., Lamkhioued, B., Tanaka, Y., Delaporte, E., Capron, A., Kinet, J.P. and Capron, M. (1994). High-affinity IgE receptor on eosinophils is involved in defence against parasites. Nature 367, 183-186. 

Kita H, Gleich GJ. Eosinophils and IgE receptors a continuing controversy. Blood... 

Rajakulasingam K, Durham S, O Brien F, Humbert M, Batata L, Reece L, Kay A, Grant J. Enhanced expression of high-affinity IgE receptor (FceRI) a chain in human allergen-induced rhinitis with co-localization to mast cells, macrophages, eosinophils, and dendritic cells. J Allergy Clin Immunol 1997 100 78-86. 

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