Idiopathic fibrosis

Asbestosis Idiopathic Fibrosis Pulmonary Edema Sarcoidosis... 

Cegla, U.H., Kroidl, R.F., Meier-Sydow, J. et al. (1975). Therapy of the idiopathic fibrosis of the lung. Experiences with three therapeutic principles corticosteroids in combination with azathioprine, D-penicillamine, and para-amino-benzoate. Pneumonologie 152, 75-92. 

Abbadie C, Lindia JA, Cumiskey AM, Peterson LB, Mudgett JS, Bayne EK, DeMartino JA, MacIntyre DE, Forrest MJ (2003) Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc Natl Acad Sci USA 100 7947-7952 Agostini C, Gurrieri C (2006) Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis. Proc Am Thorac Soc 3 357-363... 

Cantin, A.M., North, S.L., Fells, G.A., Hubbard, R.C. and Crystal, R.G. (1987). Oxidant mediated epithelial cell injury in idiopathic pulmonary fibrosis. J. Clin. Invest. 79, 1665-1675. 

IP4 Inositol tetrakisphosphate IPF Idiopathic pulmonary fibrosis IPO Intestinal peroxidase IpOCOCq Isopropylidene OCOCq I/R Ischaemia-reperfusion IRAP IL-1 receptor antagonist protein IRF-1 Interferon regulatory factor 1 la Short-circuit current ISCOM Immune-stimulating complexes... 

Findings from studies of schistosomiasis-induced liver fibrosis, as well as other models of pulmonary, kidney, and liver fibrosis, strongly support the role of CD4+ Th2 cells in the progression of fibrosis (4). In this regard, analyses of gene and protein expression after stimulation by Thl (vs. Th2) cytokines indicates that IL-4 is found at increased concentrations in the bronchoalveolar lavage (BAL) fluid of patients with idiopathic pulmonary fibrosis, as well as in the peripheral blood mononuclear cells of those afflicted with periportal fibrosis (10,53-56). 

Gauldie J. Inflammatory mechanisms are a minor component of the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2002 165(9) 1205-1206. 

Harari S, Caminati A. Idiopathic pulmonary fibrosis. Allergy 2005 60(4) 421 435. 

Abdelaziz MM, Samman YS, Wali SO, Hamad MM. Treatment of idiopathic pulmonary fibrosis is there anything new Respirology 2005 10(3) 284-289. 

Gharaee-Kermani M, Phan SH. Molecular mechanisms of and possible treatment strategies for idiopathic pulmonary fibrosis. Curr Pharm Des 2005 11(30) 3943-3971. 

Iyonaga K, Takeya M, Saita N, et al. Monocyte chemoattractant protein-1 in idiopathic pulmonary fibrosis and other interstitial lung diseases. Hum Pathol 1994 25(5) 455-463. 

Kitasato Y, Hoshino T, Okamoto M, et al. Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol... 

Capelli A, Di Stefano A, Gnemmi I, Donner CF. CCR5 expression and CC che-mokine levels in idiopathic pulmonary fibrosis. Eur Respir J 2005 25(4) 701-707. 

Selman M, Thannickal VJ, Pardo A, Zisman DA, Martinez FJ, Lynch JP, 3rd. Idiopathic pulmonary fibrosis pathogenesis and therapeutic approaches. Drugs 2004 64(4) 405-430. 

Raghu, G. et al., A placebo-controlled trial of interferon gamma-lb in patients with idiopathic pulmonary fibrosis, N. Engl. J Med, 350, 125, 2004. 

Androgen AR Human cell line Cancer, andropause, menopause, Sjogren s syndrome, idiopathic hirsutism, infertility, hypertension, mood disorders, diabetes, cystic fibrosis Immune modulation, vascular hemodynamics, neuroprotection, skeletal development, reproduction, maintenance of neuronal morphology, regulation of vasopressin Vla expression, prostatic blood flow and LH production... 

From the results of the variety of studies undertaken, it now appears certain that no one single immunological factor is responsible for the various forms of heart diseases which are seen in populations in subtropical and tropical countries. Thus, in patients with endomyocardial fibrosis (EMF), rheumatic heart disease, or idiopathic cardiomegaly, heart antibodies were present in 42% and thyroid antibodies in 15% serum cryoglobulins were present in 74% of the patients but was more frequent in those patients who had EMF than in any of the other groups (VI). The suggestion was therefore made that patients with EMF were... 

It regulates mucus production, inflammation, fibrosis and tissue remodeling. IL-13 is a therapeutic target for a number of disease states including asthma, idiopathic pulmonary fibrosis, ulcerative colitis, cancer and others. Its signaling is mediated via IL-4 type 2 receptor. The receptor consists of IL-4Ra and IL-13Ral and IL-13Ra2 chains. 

Cutaneous alternariosis (infection with Alternaria alter-nata) has been described in a 78-year-old farmer with idiopathic pulmonary fibrosis taking oral prednisone 20 mg/day (341). 

Ioannidou DJ, Stefanidou MP, Maraki SG, Panayiotides JG, Tosca AD. Cutaneous alternariosis in a patient with idiopathic pulmonary fibrosis. Int J Dermatol 2000 39(4) 293-5. 

Mariotta S, Pallone G, Li Bianchi E, Gilardi G, Bisetti A. Strongyloides stercoralis hyperinfection in a case of idiopathic pulmonary fibrosis. Panminerva Med 1996 38(l) 45-7. 

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