Idiopathic pulmonary fibrosis inflammation

It regulates mucus production, inflammation, fibrosis and tissue remodeling. IL-13 is a therapeutic target for a number of disease states including asthma, idiopathic pulmonary fibrosis, ulcerative colitis, cancer and others. Its signaling is mediated via IL-4 type 2 receptor. The receptor consists of IL-4Ra and IL-13Ral and IL-13Ra2 chains. 

Bringardner, B. D., Baran, C. P, Eubank, T. D., Marsh, C. B. The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis. Antioxid Redox Signal. 2008, 10, 287-301. 

These observation open up the possibility of TM therapy for human diseases of excessive inflammation and/or excessive fibrosis, both of which are very numerous, and some of which are quite common. A clinical trial in idiopathic pulmonary fibrosis has been initiated and others are being planned for psoriasis, primaiy biliaiy cirrhosis, scleroderma, and spondyloarthropathies. 

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