Idiopathic hirsutism

This drug reduces the growth of facial hair in idiopathic hirsutism or hirsutism that is secondary to androgen excess... 

Androgen AR Human cell line Cancer, andropause, menopause, Sjogren s syndrome, idiopathic hirsutism, infertility, hypertension, mood disorders, diabetes, cystic fibrosis Immune modulation, vascular hemodynamics, neuroprotection, skeletal development, reproduction, maintenance of neuronal morphology, regulation of vasopressin Vla expression, prostatic blood flow and LH production... 

Extreme clinical examples of androgen excess include central precocious puberty, the adrenogenital syndromes, and androgen-secreting adrenal, ovarian, or testicular tumors. Less severe problems include idiopathic hirsutism, premenstrual syndrome, and severe cystic acne. 

Spironolactone is also an androgen antagonist and as such is sometimes used in the treatment of hirsutism in women. Dosages of 50-200 mg/d cause a reduction in the density, diameter, and rate of growth of facial hair in patients with idiopathic hirsutism or hirsutism secondary to androgen excess. The effect can usually be seen in 2 months and becomes maximal in about 6 months. 

Of 65 women with idiopathic hirsutism who took either finasteride 5 mg/day or the long-acting gonadorelin agonist leuprorelin (3.75 mg monthly as an intramuscular depot), none had either menstrual abnormalities or... 

Ciotta L, Cianci A, Calogero AE, Palumbo MA, Marietta E, Sciuto A, Palumbo G. Clinical and endocrine effects of finasteride, a 5a-reductase inhibitor in women with idiopathic hirsutism. Fertil Steril 1995 64 299-306. 

Bayhan G, Bahceci M, Demirkol T, Ertem M, Yalinkaya A, Erden AC. A comparative study of a gonadotropin-releasing hormone agonist and finasteride on idiopathic hirsutism. Clin Exp Obstet Gynecol 2000 27 203-6. 

Idiopathic hirsutism is the occurrence of excessive male-pattern hair growth in women... 

Idiopathic Hirsutism (indades increased skin sensitivity to androgens)... 

Azziz R, Waggoner WT, Ochoa T, Knochenhauer ES, Boots LR. Idiopathic hirsutism An uncommon cause of hirsutism in Alabama. Fertil Steril 1998 70 274-8. 

The differentiation of normal from abnormal concentrations of plasma testosterone in women requires the use of either electron-capture GLC, isotopic-displacement methods, double-isotope methods, or fluorometric methods. Evidence to date suggests that the isotopic-displacement method is preferable (K3, M3). Existing fluorometric methods are adequate in analytical characteristics, but much more laborious (F2). This differentiation is crucial in cases of simple, provisionally idiopathic, hirsutism (cf. however. Cl). In many cases, however, an elevated excretion of urinary testosterone glucuronide would be equally satisfactory despite the uncertainty of its metabolic precursors (B2, II). This measurement is also desirable in cases of provisionally idiopathic amenorrhea. 

B2. Bardin, C. W., Hembree, W. C., and Lipsett, M. B., Suppression of testosterone and androstenedione production rates with dexamethasone in women with idiopathic hirsutism and polycystic ovaries. J. Clin. Endocrinol. 28, 1300-1306... 

Cl. Casey, J. M., and Nabarro, J. D. N., Plasma testosterone in idiopathic hirsutism and the changes produced by adrenal and ovarian stimulation and suppression. /. Clin. Endocrinol. 27, 1431-1435 (1967). 

N5a. Nichols, T., Nugent, C. A., and Tyler, F. H., Glucocorticoid suppression of urinary testosterone excretion in patients with idiopathic hirsutism. J. Clin. Endocrinol. 26, 79-86 (1966). 

In a study of women with idiopathic hirsutism (excessive male pattern hair growth in women with normal levels of serum androgens), involving topical application of a cream containing 1 or 2% fennel ethanol extract daily for 8 or 12 weeks, a dose-dependent reduction in hair diameter was observed. The authors of the article indicated that estrogenic activity of fennel was responsible for this reduction (Javidnia et al. 2003). 

The use of 43a (50-600 mg/day, p.o.) was temporarily effective in the treatment of acne and idiopathic hirsutism.The related 43b was effective in reducing sebum production in the rat, but it also exhibited weak, but definite uterotrophlc activity. 2,143 stimulating effect... 

A cream containing 2% of the ethanolic extract of fennel was effective in reducing excessive hair growth in women diagnosed with idiopathic hirsutism. ... 

Flirsutism, virilization 21-FIydroxylase defect (simple virilizing, late onset) lip FIydroxylase defect Sp iTydroxysteroid dehydrogenase defect Adrenal tumors Gonadal tumors Polycystic ovaries Cortisone reductase deficiency Idiopathic hirsutism... 

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