Nicotinic acid and derivatives

Reinbothe, H., Miersch, J., Mothes, K. Special problems of nitrogen metabolism in plants. Compr. Biochemistry 19 A, 51-63 (1981) 

Wasternack, C. Metabolism of pyrimidines and purines. In Encyclopedia of Plant Physiology, New Series, Vol. 14b Nucleic Acids and Proteins in Plants (B. Parthier, D. Boulter, ed.), pp. 263-301. Springer, Berlin-Heidelberg-New York 1982 

Nicotinic acid, pyridine 3-carboxylic acid, is the mother substance of a group of pyridine derivatives. Most of these substances contain a carboxy group or another substituent, e.g., an iV-heterocyclic ring in position 3. Oxygen functions, especially in the positions 2, 4 and 6 and iV-methyl groups may be present. 

Nicotinic acid and structurally related compounds are synthesized in microorganisms, plants, and animals. 

In most bacteria and in higher plants nicotinic acid is formed from aspartic acid and a three carbon unit derived from glycerol, probably D-glyceraldehyde-3-phosphate (D 2). A key intermediate is quinolinic acid, which in animals, however, is derived from l-tryptophan (D 21). Nicotinic acid originates from quinolinic acid via nicotinic acid mononucleotide formed with the participation of 5-phosphoribosyl-l-pyrophosphate. It changes either directly to nicotinic acid or is formed via nicotinamide adenine dinucleotide (NAD+) in the nicotinic acid nucleotide cycle. 

---

Growth Effects of Nicotinic Acid and Derivatives on T. pyriformis ... 

Drugs used in treatment statins fibric acid derivatives anion-exchange resins nicotinic acid and derivatives... 

---