Sesquiterpene glycosides

A sesquiterpene glycoside, nerolidol-3-O-a-L-rhamnopyranosyl (l )-a-L-rhamnopyranosyl (1 2)-[a-L-rhamnopyranosyl(1 6)]-P-D-glucopyranoside (66) isolated from Eriobotrya japonica (Thunb.) Lindl. (family Rosaceae), showed a significant (p < 0.05) hypoglycemic effect in alloxan-induced diabetic rats when administered orally to alloxan-diabetic mice at doses of 25 and 75 mg/kg however, the dosage... 

Chen J, Fi WL, Wu JL, Ren BR, Zhang HQ. (2008) Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.). Phytomedicine 15 98-102. 

De Tommasi N, De Simone F, Aquino R. (1990) Plant metabolites, new sesquiterpene glycosides from Eriobotrya japonica. JNat Prod 53 810-815. 

Kodama, H., T. Fujimori, and K. Kato. Structure determination of new sesquiterpene glycosides from flue-cured tobacco by two dimensional NMR. Proc 26th Symposium on the Chemistry of Natural Products, Kyoto, Japan 1983 26 1-8. 

Cui, C-B. et al.. Constituents of a fern, Davallia mariessi Moore. IV. Isolation and structures of a novel norcarotane sesquiterpene glycoside, a chromone glucuronide, and two epicatechin glycosides, Chem. Pharm. Bull, 40, 2035, 1992. 

Zhao CS, Liu QF, Halaweish F, Shao BP, Ye YQ, Zhao WM (2003) Copacamphane, Picrotoxane, and Alloaromadendrane Sesquiterpene Glycosides and Phenolic Glycosides from Dendrobium moniliforme. J Nat Prod 66 1140... 

Shu Y, Zhang DM, Guo SX (2004) A New Sesquiterpene Glycoside from Dendrobium nobile Lindl. J Asian Nat Prod Res 6 311... 

Ye QH, Qin GW, Zhao WM (2002) Immunomodulatory Sesquiterpene Glycosides from Dendrobium nobile. Phytochemistry 61 885... 

Zhao WM, Ye Q, Tan X, Jiang H, Li X, Chen K, Kinghom AD (2001) Three New Sesquiterpene Glycosides from Dendrobium nobile with Immunomodulatory Activity. J Nat Prod 64 1196... 

An acyclic sesquiterpene glycoside, mukurozioside Ilb (13), which was identified previously fi om Sapindus mukurossi Gaertn. (Sapindaceae) [68], was isolated fi om the fruits of Sapindus rarak DC. (Sapindaceae) from Indonesia (6.8% w/w yield) [47]. The sweetness of this compoimd has been rated as about the same as that of 2% sucrose by a small taste panel [47]. This is the first acyclic sesquiterpene glycoside fi-om a plant source to have been determined to have a sweet taste. Altiiough its sweetness potency is equivalent to those of the bulk sweeteners, this... 

FIVE NOVEL SESQUITERPENE GLYCOSIDES FROM DICTAMNUS... 

Key v/ords-Dictamnus dasycarpus, Rutaceae, sesquiterpene glycosides, dictaninosides A-E. 

Abstract—Five novel sesquiterpene glycosides named dictamnosides A-E (1-5) were isolated from the methanol extract of the root bark of Dictamnus dasycarpus (Rutaceae). Their structures were established on the basis of X-ray diffraction, spectroscopic and chemical methods. 

De Tommasi, N., F. De Simone, G. Cirino, C. Cicala, and C. Pizza. 1991. Hypoglycemic effects of sesquiterpene glycosides and polyhydroxvlated triterpenoids of Eriobotrya japonica. Planta Med. 57(5) 414-416. 

The fruits, kernel and leaves of loquat are all used for medicinal purpose. The leaf of loquat is a well known Traditional Chinese Medicine used as anti-tussive and anti-inflammatory agent for acute and chronic bronchitis. Phytochemical studies 1-5) with this species have led to the isolation of many natural products including flavonoids, triterpenes and sesquiterpene glycoside. Some of the components have been found to have antioxidant (2), antiviral (4), cytotoxic (/) and hypoglycemic (5) properties. In the course of ongoing search for anti-tussive and anti-inflammatory components from this plant, an ethanolic extract of the leaves of . japonica was examined. We report here the isolation and structural determination of three new components as well as seventeen known compounds. 

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