Hypertext links

Of each type of window, at most one is visible at a time. Those strongly outlined are always visible the current title, copy, member, and hire. Italics show information only displayed in certtain states. Underlined items are hypertext links —navigation as shown. 

Account (with a pluggable routine for displaying External Reason as a hypertext link that can be queried further)... 

After a brief introduction that sets the work described into a broader context, the report focuses on how a molecular understanding can provide explanations of observed biology and lead to therapies for diseases. Each vignette is accompanied by a figure and hypertext links that lead to a series of pages that interactively show how NCBI tools and resources are used in the research process. 

Hypertext linking and bookmarks Bookmarks and hypertext links should be provided for each item listed in the table of contents, including tables, figures, publications, other references, and appendices. Hypertext links should be used throughout the document for supporting annotations, related sections, references, appendices, tables, figures. 

The EDR is an extension of the central document room. We perform a check on each submission sent to the EDR for file formats used and for integrity of bookmarks and hypertext links. 

The electronic IND also features the use of the roadmap.pdf. This is the recommended entry point for the electronic submission. The roadmap, pdf should contain functional hypertext links to the original submissions main TOC and to each subsequent submission s TOC. You should include the submission serial number found in the prefix of each file for that submission (see Appendix A). You should update and resubmit this file with each amending submission. As a result, the roadmap.pdf always will contain a current comprehensive submission history that will enable a reviewer to easily access the original IND and its subsequent amendments through their main TOCs. 

Bookmarks and Hypertext Links. For all documents with a TOC, you should provide bookmarks and hypertext links for each item in the document s TOC including all tables, figures, publications, and appendices even if included in a separate file, to serve as part of the TOC for the submission. 

To facilitate the review, you should provide hypertext links to supporting annotations, related sections, references, appendices, tables, or figures that are not located on the same page throughout the body of the document. For a reference list at the end of a document, you should provide a hypertext link from the item listed to the appropriate PDF publication file. In order to provide reviewers maximal flexibility in using electronic documents, please avoid linking items across submission folders. We intend to review the information according to discipline and thus you should present your information in a modular fashion. For example, if you intend to use a reference to support a point in the CMC folder, you should not place the reference in the Clinical folder. 

Publications. You should provide each publication as a separate PDF hie. Establish a hypertext link between the reference to the publication in the application and the publication. You should include the citation for the publication in the title portion of the Document Information held for each publication hie. 

For the electronic submission, the TOC should contain three levels of detail and the appropriate hypertext links and bookmarks (see Appendix B). The first level of detail, the main TOC, will contain a simple listing of the items in section 12 of the Form FDA 1571. You should hypertext link and bookmark these items to the appropriate item TOC for the IND. This single-page PDF file should be named XXXX indtoc.pdf where XXXX is the submission serial number. You should place the main TOC in the main folder. 

Responses to Center Correspondence You should include the actual comments, questions, and requests for additional information communicated in our letter sent to you, as well as your response to these items. You should bookmark each item to facilitate information access and make additional supporting information accessible through a hypertext link contained within your response. 

Publications You should provide each publication as a separate PDF file. You should place in alphabetical order and into a single folder named pubs all publications that are cited in files contained in the admin folder. You should establish a hypertext link between the citation and the publication in the pubs folder. Place the pubs folder in the admin folder. You should include the citation for the publication in the Title portion of the Document Information field for each publication file. You should include the first author s last name, the year of the publication, and the title of the article in the citation. 

Protocol and Protocol Revisions (amendments) You should provide each protocol in a separate PDF file in a subfolder labeled Protocols. To help us easily identify the file, use the protocol number as part of the file name. Each protocol should have a TOC. You should hypertext link and bookmark the TOC. For protocol revisions or amendments, you should use the same protocol number that identifies the original protocol. You should submit to tie file a complete copy of any revised protocol. This will facilitate the use of the text compare function in Adobe Acrobat by our clinical reviewers. 

You should create a PDF file namedprotocolctoc.pdf (i.e., protocol cumulative TOC) within the Protocols subfolder. The protocolctoc.pdf is a cumulative list of the protocols and revisions with the date of submission presented as a PDF file. The cumulative list should be in inverse chronological order, with the most recent protocol submission at the top of the list. Because this file is cumulative, it does not have a numerical prefix. The protocolctocpdf should not affect the submission content in any fashion. You should hypertext link the protocols and revisions listed in this file to the documents they reference. You should update this file with the submission of any protocol or protocol revision. The document should function in a manner similar to the roadmap, pdf file (see Appendix A and Appendix B, Figure VI-4). 

Investigator s Brochure You should provide the Investigator s Brochure as a single PDF file. You should include a TOC in the Investigator s Brochure. You should name the file XXXX investbrochuretoc.pdf. You should bookmark and hypertext link the TOC for this file. 

You should use the roadmap.pdf file to establish a hypertext link to the submission s TOC. You should locate the roadmap.pdf file in the root directory of the submission. You should update and resubmit the file when you submit amendments to the application. An example of the roadmap.pdf file format is shown in Fig. VI-1. 

IND submission Submission date Submission content CD-ROM Hypertext link destination... 

The accuracy of the references is the author s responsibility. Errors in references are one of the most common errors found in scientific publications and are a source of frustration to readers. Increasingly, hypertext links are automatically generated in Web-based publications, but this cannot be done for references containing errors. If citations are copied from another source, check the original reference for accuracy and appropriate content. 

References are an important component of every scholarly manuscript. Having complete and accurate references is the author s responsibility. Errors in references are one of the most common mistakes authors make. Although correct citations have always been important, the increasing number of hypertext links in Web-based publications makes correct citations more important than ever. Given the volume of manuscripts that publishers produce yearly, technical editors cannot verify each reference in each manuscript. 

Reminder Although correct citations have always been important, the increasing number of hypertext links in Web-based publications makes correct citations more important than ever. 

To assist the interpretation of family memberships, overall probability scores for both global and motif matches are provided for top hit families. The global score is computed from the BLAST e-value, the SSEARCH score, and the percentage of sequence identity at overlapped length ratio in SSEARCH alignment. The motif score is computed from the ratio of mismatched amino acids to ProSite patterns, and the hidden Markov motif match score. Family information from ProClass, with hypertext links to all other major family... 

The web is the most popular Internet application. It allows easy links to information and files which may be located on computers anywhere in the world. The WWW allows access to millions of home pages or websites , the initial point of reference with companies, institutes and individuals. Besides their own text and images, these contain hypertext links , highlighted words or phrases that you chck on to take you to another page on the same website or to a completely different site with related subject material. Certain sites specialize in such links, acting like indexes to other websites these are particularly useful. 

A common way to find information on the Internet is by browsing ( surfing ) the World Wide web (WWW). However, as this can be time consuming and wasteful, browsing should be focused on relevant sites. Many of the most useful websites are those providing detailed lists and hypertext links to other locations. A useful place to find out what the Internet offers the chemist can be found at the URL http //www.chemdex.org. 

US Environmental Protection Agency (US EPA) (1996) Exposure Factors Handbook. Washington, DC Office of Health and Environmental Assessment, Office of Research and Development, USEPA. Volume I, PB98-124225 Vol. II, PB98-124233 Vol. Ill PB98-124241 and the set of three volumes is PB98-124217. US EPA has also produced a CD-ROM that contains an interactive version of the Exposure Factors Handbook. The CD-ROM has word search capabilities, downloadable tables, hypertext links to various chapters in the document, and key references. 

Hypertext links can be created among a group s various corporate sites. 

The rapid development in information technology (IT) in recent years has revolutionised the availability and speed of retrieval of information. Many reference sources are now available on CD-ROM, which are generally much easier to store, access and search than books and journals. The introduction of the World Wide Web (WWW), with a user-friendly graphical interface based on hypertext links, provides easy access via the Internet to a wealth of information and databases which are kept continually updated (D Emanuele 1996). Some of the useful Web sites for sources of information about pharmaceutical development and regulatory guidelines are listed in Table 8.2. The Web site addresses are correct at the time of this writing. 

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