Hyperbranched polyamine

Hyperbranched aromatic polyesters, synthesis of, 116-118 Hyperbranched aromatic polymers, 286 Hyperbranched polyamine, synthesis of, 519-520... 

Suzuki et al. [14] reported the Pd-catalyzed ring-opening polymerization of a cyclic carbamate in the presence of an initiator, which also acts as a core molecule, to afford a hyperbranched polyamine. The polymerization was proposed to be an in situ multibranching process, wherein the number of propagating chain ends increase with the progress of the polymerization. 

This review deals with the syntheses of various hyperbranched polyamines that are prepared through a one-step polymerization process. Furthermore, we present the current status of polyamines as gene carriers and describe their versatility, and their properties such as structure-property dependency, gene transfection efficiency, and cytotoxicity profiles of hyperbranched polyamines. 

Keywords Applications Cytotoxicity profile Gene delivery Hyperbranched polyamines Poly(amido amine) Poly(amido ester) Poly(ethylene imine) Polyglycerol amines Structure-property dependence Synthesis Transfection efficiency... 

Our group described a simple access to well-defined hyperbranched polyamines from hyperbranched PEI with different molecular weights, narrow molecular weight distributions, and an adjustable degree of branching [91]. According to this protocol fully branched analogs of polypropyleneimine (PPI) and polyamidoa-mine (PAMAM) dendrimers can be derived from hyperbranched PEI (Mw = 5,000, and 25,000 g mol-1) in a two-step synthetic process (Scheme 2). 

Scheme 2 Synthesis pathway of hyperbranched polyamines, PEI/PAMAM and PEI/PPI based on hyperbranched PEI (a) PEI/PAMAM (1) CH2=CHCOOMe, THF, 25°C, 4 days, (2) CH2=CHOOMe, 25°C, 8 days, and finally (3) H2NCH2CH2NH2, 50°C, 8 days, THF (b) PEI/ PPI (1) CH2=CHCN in water, 25°C, 2 days and (2) LiAlfVAlCb, in THF, 25°C, 1 day. Reproduced with permission from [91]. Copyright 2004 Wiley...

Suzuki et al.[57 explored the Pd-catalyzed ring-opening of the monomer 5,5-dimethyl-6-ethenylperhydro-l,3-oxazin-2-one to give a hyperbranched polyamine. The polymerization was conducted at ambient temperature in THF and catalyzed with Pd2(dba)3-2 dppe, affording after the evolution of carbon dioxide, the desired hyperbranched polyamine. NMR spectroscopy confirmed the high yield conversion of the monomer. The degree of branching was ascertained (from NMR data) as the ratio of tertiary amine units to the total of secondary and tertiary moieties. 

Poly(ethylene terephthalate) functionalized with hyperbranched polyamine cations was prepared by Rao [3] and used to splay layered materials in a matrix in polymer-layered nanotubes. 

MFSO = Mesua ferrea L. seed oil LO = linseed oil, DCO = dehydrated castor oil, NSO = Niger seed oil, ASO = Annona squamosa oil, PGO = Pongamia glabra oil, DEA = diethanolamine, PA = phthalic anhydride, MA= maleic anhydride, AA = adipic acid, lA = isophthalic acid, CV = MEKP, co-octate and styrene-based curing system, TEA = triethylamine, HMMM = hexamethoxymethylmelamine, VA = vinyl acetate and SMA = poly(styrene-co-maleic anhydride), HBPA = hyperbranched polyamine. 

S. S. Mahapatra and N. Karak, Hyperbranched polyamine A promising curing agent for a vegetable oil-based poly(ester-amide) resin . Prog Org Coat, 2007, 60, 328-34. 

S. S. Mahapatra and N. Karak, Hyperbranched polyamine A promising agent... 

Fischer W, Calderon M, Haag R (2010) Hyperbranched polyamines for transfection. Top Curr Chem 296 95-129... 

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